ATRX Antibodies

AND ATRX ELISA kits, ATRX Proteins

Many biological assays use antibodies to detect ATRX, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ATRX in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ATRX antibodies...

We validate the specificity of these antibodies to ATRX by testing them on tissues known to express ATRX positively and negatively. Browse below to find the ATRX antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ATRX Infographic by Boster Bio

All ATRX Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Transcriptional regulator ATRX ATRX Antibody

1 Citations 15 Q&As

Human, Mouse

$360
Cat # A00203-1
100 µl

Anti-ATRX / RAD54 (Alpha Thalassemia Mental Retardation) Monoclonal Antibody

1 Citations 3 Q&As

Human

IHC

$486
Cat # M00203
100ug/vial

Anti-ATRX Antibody Picoband®

1 Citations 6 Q&As

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A00203-2
100 μg/vial

ATRX Overview

Facts about Transcriptional regulator ATRX.

ATRX 3D structure. Source: alphafold

Transcriptional regulator ATRX (ATRX)

Facilitates DNA replication in multiple mobile environments and is necessary for efficient replication of a subset of genomic loci. May help stabilizing G-rich regions into routine chromatin structures by remodeling G4 DNA and integrating H3.

3- containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX that has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.

Gene Information

Human
Gene Name:	ATRX
Uniprot:	P46100
Entrez:	546

Family

Belongs to:

SNF2/RAD54 helicase family

Alternative Names

alpha thalassemia/mental retardation syndrome X-linked (RAD54 (S. cerevisiae)homolog); alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S.cerevisiae); alpha thalassemia/mental retardation syndrome X-linked; ATP-dependent helicase ATRX; ATR2; DNA dependent ATPase and helicase; EC 3.6.1; EC 3.6.4.12; helicase 2, X-linked; Juberg-Marsidi syndrome; MGC2094; MRXHF1; RAD54 homolog; RAD54L; SFM1; SHS; transcriptional regulator ATRX; XH2RAD54; X-linked helicase II; X-linked nuclear protein; XNPZNF-HX; Zinc finger helicase; Znf-HX

Molecular Weight

Mass (kDA):
282.586 kDA

Genomic Context


Human

Location:	Xq21.1
Sequence:	X; NC_000023.11 (77504878..77786235, complement)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Nucleus. Chromosome, telomere. Nucleus, PML body. Associated with pericentromeric heterochromatin during interphase and mitosis, probably by interacting with CBX5/HP1 alpha. Colocalizes with histone H3.3, DAXX, HIRA and ASF1A at PML-nuclear bodies. Colocalizes with cohesin (SMC1 and SMC3) and MECP2 at the maternal H19 ICR (By similarity).

Diseases

Alpha-thalassemia
Alpha-thalassemia/mental Retardation Syndrome, Nondeletion Type, X-linked
Thalassemia
Neoplasms
Leukemia
Severe Mental Retardation
Malignant Neoplasms
Dysmyelopoietic Syndromes
Acute Promyelocytic Leukemia
Congenital Anomaly Of Face

Cytomegalovirus Infections
Hereditary Diseases
Pancreatic Neoplasm
Neuroendocrine Tumors
Urogenital Abnormalities

Interacting Proteins

CBX5
DAXX
EZH2
Mecp2
RAD50

Pathways

Chromatin Remodeling
Methylation
Localization
Dna Methylation
Pathogenesis
Mitosis
Cell Cycle
Meiosis
Brain Development
Metaphase
Sex Determination
Atp-dependent Chromatin Remodeling
Sex Differentiation

Spermatogenesis
Interphase
Regulation Of Gene Expression
Cell Death
Cell Proliferation
S Phase
Chromosome Segregation

PTMs

Methylation
Phosphorylation
Sumoylation

Deacetylation
Cleavage
Amidation

Acetylation

Research Areas

Cancer
Checkpoint signaling
DNA Double Strand Break Repair
DNA Repair

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATRX

References

PMID: 8968741 by Picketts D.J., et al. ATRX encodes a novel member of the SNF2 family of proteins: mutations point to a common mechanism underlying the ATR-X syndrome.

PMID: 9244431 by Villard L., et al. Determination of the genomic structure of the XNP/ATRX gene encoding a potential zinc finger helicase.

1 Publications of Boster ATRX Antibodies & ELISA Kits

PubMed ID: -, Co-occurrence of ATRX and IDH Mutations Identify Subgroup of Glioma Patients for...

*More publications can be found for each product on its corresponding product page