ATR Antibodies

AND ATR ELISA kits, ATR Proteins

Many biological assays use antibodies to detect ATR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ATR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ATR antibodies...

We validate the specificity of these antibodies to ATR by testing them on tissues known to express ATR positively and negatively. Browse below to find the ATR antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: A1BG Next: AUH

ATR Infographic by Boster Bio

All ATR Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-ATR Antibody

1 Q&As

Human

ELISA, WB

$629
Cat # A00262
100ug

Anti-Phospho-ATR (S428) Antibody

Human

ELISA, IHC

$380
Cat # A00262S428
100ul

Anti-ATR Antibody

Human

ELISA, IHC, WB

$380
Cat # A00262-1
100ul

Anti-ATR Antibody

Human

ELISA, IF, ICC

$370
Cat # A00262-2
100 μg/vial

Anti-ATR Antibody Picoband®

Human

ELISA, Flow Cytometry, WB

$370
Cat # A00262-3
100 μg/vial

ATR Overview

Facts about Serine/threonine-protein kinase ATR.

ATR 3D structure. Source: alphafold

Serine/threonine-protein kinase ATR (ATR)

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q.

Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which jointly inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism.

Gene Information

Human
Gene Name:	ATR
Uniprot:	Q13535
Entrez:	545

Family

Belongs to:

PI3/PI4-kinase family

Alternative Names

ataxia telangiectasia and Rad3 related; Ataxia telangiectasia and Rad3-related protein; ATR; EC 2.7.11.1; FRAP-related protein 1; FRP1; FRP1FRAP-related protein-1; MEC1; protein kinase ATR; Rad3 related protein; SCKL1; SCKLMEC1, mitosis entry checkpoint 1, homolog; serine/threonine-protein kinase ATR

Molecular Weight

Mass (kDA):
301.367 kDA

Genomic Context


Human

Location:	3q23
Sequence:	3; NC_000003.12 (142449235..142578793, complement)

Tissue Specificity

Ubiquitous, with highest expression in testis. Isoform 2 is found in pancreas, placenta and liver but not in heart, testis and ovary.

Subcellular Localizations

Nucleus. Nucleus, PML body. Chromosome. Depending on the cell type, it can also be found in PML nuclear bodies. Recruited to chromatin during S-phase. Redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling.