ATP6V0A4 Antibodies

AND ATP6V0A4 ELISA kits, ATP6V0A4 Proteins

Many biological assays use antibodies to detect ATP6V0A4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ATP6V0A4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ATP6V0A4 antibodies...

We validate the specificity of these antibodies to ATP6V0A4 by testing them on tissues known to express ATP6V0A4 positively and negatively. Browse below to find the ATP6V0A4 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: SEPTIN9 Next: ITSN2

ATP6V0A4 Infographic by Boster Bio

All ATP6V0A4 Products

Product

Figures

Specificity

Applications

Price

ATP6V0A4 (NM_020632) Human Recombinant Protein

$1249
Cat # PROTQ9HBG4
20 µg

ATP6V0A4 (NM_020632) Human Over-expression Lysate

Human

$960
Cat # LS050617
100 µg

ATP6V0A4 Overview

Facts about V-type proton ATPase 116 kDa subunit a isoform 4.

ATP6V0A4 3D structure. Source: alphafold

V-type proton ATPase 116 kDa subunit a isoform 4 (ATP6V0A4)

Part of the proton channel of the V-ATPase that's involved in normal vectorial acid transport into the urine from the kidney. .

Gene Information

Human
Gene Name:	ATP6V0A4
Uniprot:	Q9HBG4
Entrez:	50617

Family

Belongs to:

V-ATPase 116 kDa subunit family

Alternative Names

A4; ATP6N2; ATP6V0; ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1B; ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kD); ATPase, H+ transporting, lysosomal V0 subunit a4; MGC130016; MGC130017; noncatalytic accessory protein 1B; RDRTA2; RTA1C; RTADR; STV1; vacuolar proton pump 116 kDa accessory subunit; vacuolar proton pump, subunit 2; vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform; V-ATPase 116 kDa; VPH1; VPP2; V-type proton ATPase 116 kDa subunit a isoform 4; V-type proton ATPas

Molecular Weight

Mass (kDA):
96.386 kDA

Genomic Context


Human

Location:	7q34
Sequence:	7; NC_000007.14 (138706294..138799839, complement)

Tissue Specificity

Expressed in adult and fetal kidney. Found in the inner ear.

Subcellular Localizations

Apical cell membrane; Multi-pass membrane protein. Present at high density almost exclusively on the apical surface of alpha-intercalated cells in the cortical collecting ducts of the distal nephron.

Diseases

Acidosis
Renal Tubular Acidosis
Renal Tubular Acidosis, Type I
Sensorineural Hearing Loss (disorder)
Complete Hearing Loss
Renal Tubular Acidosis, Distal, Autosomal Recessive
Metabolic Acidosis
Nephrocalcinosis
Hypercalciuria
Disease Of Adrenal Medulla
Malignant Neoplasms
Nephrolithiasis
Proximal Renal Tubular Acidosis

Weakness
Malignant Neoplasm Of Breast
Glioma
Hyperammonemia
Speech Delay
Neoplasms
Fanconi Syndrome

Pathways

Transport
Localization
Excretion
Secretion
Proton Transport
Pathogenesis
Reverse Transcription
Endocytosis

Glycolysis
Kidney Development
Acid Secretion

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATP6V0A4

References

PMID: 10973252 by Smith A.N., et al. Mutations in ATP6N1B, encoding a new kidney vacuolar proton pump 116- kD subunit, cause recessive distal renal tubular acidosis with preserved hearing.

PMID: 12414817 by Stover E.H., et al. Novel ATP6V1B1 and ATP6V0A4 mutations in autosomal recessive distal renal tubular acidosis with new evidence for hearing loss.