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ATP6AP1 Antibodies
AND ATP6AP1 ELISA kits, ATP6AP1 Proteins
Many biological assays use antibodies to detect ATP6AP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ATP6AP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ATP6AP1 antibodies...
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ATP6AP1 Overview
Facts about V-type proton ATPase subunit S1.
V-type proton ATPase subunit S1 (ATP6AP1)
Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is needed for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity.
Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex.
Gene Information
| Human | |
|---|---|
| Gene Name: | ATP6AP1 |
| Uniprot: | Q15904 |
| Entrez: | 537 |
Family
| Belongs to: |
|---|
| vacuolar ATPase subunit S1 family |
Alternative Names
16A; Ac45; ATP6IP1V-ATPase subunit S1; ATP6S1ORF; ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1; ATPase, H+ transporting, lysosomal accessory protein 1; H+ transporting, lysosomal interacting protein 1; H-ATPase subunit; MGC129781; Protein XAP-3; Vacuolar proton pump subunit S1; VATPS1V-ATPase Ac45 subunit; V-type proton ATPase subunit S1; XAP-3; XAP3V-ATPase S1 accessory protein
Molecular Weight
Mass (kDA):
52.026 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq28 |
| Sequence: | X; NC_000023.11 (154428669..154436516) |
Tissue Specificity
widely expressed, with highest levels in brain and lowest in liver and duodenum.
Subcellular Localizations
Endoplasmic reticulum membrane; Single-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Not detected in trans-Golgi network.
Diseases
- Albers-schonberg Disease
- Infantile Malignant Osteopetrosis
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasms
- Neoplasms
- Osteoporosis
- Compression Of Optic Nerve
- Hereditary Diseases
- Retinal Degeneration
- Nerve Compression
- Sclerosis
- Neoplasm Metastasis
- Disease Of Adrenal Medulla
Pathways
- Bone Resorption
- Endocytosis
- Secretion
- Osteoclast Differentiation
- Receptor-mediated Endocytosis
- Secretory Pathway
- Localization
- Cell Cycle
- Cell Proliferation
- Glycosylation
- Transport
- Cell Activation
- Proton Transport
PTMs
- Cleavage
- Carboxylation
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATP6AP1
bosterbio.com/bosterbio-gene-info-cards/ATP6AP1
References
PMID: 8733135 by Chen E.Y., et al. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci.
PMID: 8034313 by Yokoi H., et al. Isolation of expressed sequences encoded by the human Xq terminal portion using microclone probes generated by laser microdissection.