ATP13A2 Antibodies

AND ATP13A2 ELISA kits, ATP13A2 Proteins

Many biological assays use antibodies to detect ATP13A2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ATP13A2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ATP13A2 antibodies...

We validate the specificity of these antibodies to ATP13A2 by testing them on tissues known to express ATP13A2 positively and negatively. Browse below to find the ATP13A2 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ATP13A2 Infographic by Boster Bio

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ATP13A2 Overview

Facts about Cation-transporting ATPase 13A2.

ATP13A2 3D structure. Source: alphafold

Cation-transporting ATPase 13A2 (ATP13A2)

ATPase that plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity (PubMed:22186024). Required for a proper lysosomal and mitochondrial maintenance (PubMed:22296644, PubMed:28137957).

Gene Information

Human
Gene Name:	ATP13A2
Uniprot:	Q9NQ11
Entrez:	23400

Family

Belongs to:

cation transport ATPase (P-type) (TC 3.A.3) family

Alternative Names

ATPase type 13A2; EC 3.6.3; EC 3.6.3.-; EC 3.6.3.5; EC 3.6.3.8; FLJ26510; HSA9947; KRPPD; PARK9putative ATPase; Parkinson disease (autosomal recessive) 9 (Kufor-Rakeb syndrome); probable cation-transporting ATPase 13A2

Molecular Weight

Mass (kDA):
128.794 kDA

Genomic Context


Human

Location:	1p36.13
Sequence:	1; NC_000001.11 (16985958..17011972, complement)

Tissue Specificity

Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex (at protein level). In the substantia nigra, it is found in neuromelanin- positive dopaminergic neurons (at protein level).

Subcellular Localizations

Membrane; Multi-pass membrane protein. Lysosome. Lysosome membrane.

Diseases

Parkinson Disease
Secondary Parkinson Disease
Neurodegenerative Disorders
Nerve Degeneration
Dementia
Movement Disorders
Atrophy
Juvenile Parkinson's Disease
Impaired Cognition
Lewy Body Disease
Parkinsonism, Autosomal Recessive
Neurotoxicity Syndromes

Ataxia
Neuroblastoma
Alzheimer's Disease
Cerebral Atrophy
Neuronal Ceroid-lipofuscinoses
Manganese Poisoning

Interacting Proteins

AAK1
BNIP3L
GAK
HDAC6
HSPA8

SYT11
YIF1A

Pathways

Pathogenesis
Transport
Cell Death
Autophagy
Dna Methylation
Cation Homeostasis
Localization
Methylation
Translation
Secretory Pathway
Vesicle Transport
Gene Silencing
Neurogenesis

Neuron Development
Myelination
Cell Division
Neuroprotection
Macroautophagy
Cell Cycle
Cell Growth

PTMs

Phosphorylation

Methylation

Ubiquitination

Research Areas

Cancer
Neurodegeneration
Neuroscience
Plasma Membrane Markers
Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATP13A2

References

PMID: 22186024 by Ramonet D., et al. PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity.

PMID: 16964263 by Ramirez A., et al. Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase.