Atlastin-3 Antibodies

AND ATL3 ELISA kits, Atlastin-3 Proteins

Many biological assays use antibodies to detect Atlastin-3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Atlastin-3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Atlastin-3 antibodies...

We validate the specificity of these antibodies to Atlastin-3 by testing them on tissues known to express ATL3 positively and negatively. Browse below to find the ATL3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ATL3 Infographic by Boster Bio

All ATL3 Products

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Specificity

Applications

Price

ATL3 (NM_015459) Human Recombinant Protein

$813
Cat # PROTQ6DD88
20 µg

ATL3 (NM_015459) Human Over-expression Lysate

Human

$628
Cat # LS025923
100 µg

ATL3 Overview

Facts about Atlastin-3.

ATL3 3D structure. Source: alphafold

Atlastin-3 (ATL3)

GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed:18270207, PubMed:19665976, PubMed:27619977).

Gene Information

Human
Gene Name:	ATL3
Uniprot:	Q6DD88
Entrez:	25923

Family

Belongs to:

TRAFAC class dynamin-like GTPase superfamily

Alternative Names

atlastin 3; atlastin GTPase 3; atlastin-3; DKFZP564J0863; EC 3.6.5.-

Molecular Weight

Mass (kDA):
60.542 kDA

Genomic Context


Human

Location:	11q13.1
Sequence:	11; NC_000011.10 (63624082..63671974, complement)

Tissue Specificity

Expressed in the central nervous system and in dorsal root ganglia neurons. Expressed in peripheral tissues (at protein level).

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein. Localizes to endoplasmic reticulum tubules and accumulates in punctuate structures corresponding to 3-way junctions, which represent crossing-points at which the tubules build a polygonal network.

Diseases

Stomatitis
Vesicular Stomatitis
Muscle Spasticity
Idiopathic Pulmonary Hypertension
Weakness
Spastic Paraplegia, Hereditary
Nervous System Disorder
Pathological Dilatation
Hypertensive Disease

Peroneal Muscular Atrophy With Pyramidal Features, Autosomal Dominant
Paraplegia
Spastic Paraplegia
Pulmonary Hypertension

Pathways

Secretory Pathway
Pathogenesis
Localization

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATL3

References

PMID: 14506257 by Zhu P.-P., et al. Cellular localization, oligomerization, and membrane association of the hereditary spastic paraplegia 3A (SPG3A) protein atlastin.

PMID: 18270207 by Rismanchi N., et al. Atlastin GTPases are required for Golgi apparatus and ER morphogenesis.