Zinc finger protein 521 Antibodies

AND ZNF521 ELISA kits, Zinc finger protein 521 Proteins

Many biological assays use antibodies to detect Zinc finger protein 521, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Zinc finger protein 521 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Zinc finger protein 521 antibodies...

We validate the specificity of these antibodies to Zinc finger protein 521 by testing them on tissues known to express ZNF521 positively and negatively. Browse below to find the ZNF521 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ZNF521 Infographic by Boster Bio

All ZNF521 Products

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Anti-Zinc finger protein 521 ZNF521 Antibody

Human

ELISA, IHC-P

$449
Cat # A06292
0.1 mg

Anti-Zinc finger protein 521 ZNF521 Antibody

Human

ELISA, IF, ICC, WB

$449
Cat # A06292-1
0.1 mg

ZNF521 (NM_015461) Human Over-expression Lysate

Human

$960
Cat # LS025925
100 µg

ZNF521 Overview

Facts about Zinc finger protein 521.

ZNF521 3D structure. Source: alphafold

Zinc finger protein 521 (ZNF521)

Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system.

Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes.

Gene Information

Human
Gene Name:	ZNF521
Uniprot:	Q96K83
Entrez:	25925

Family

Belongs to:

krueppel C2H2-type zinc-finger protein family

Alternative Names

EHZF; Evi3; LIP3; ZFP521; zinc finger protein 263; Zinc finger protein FPM315; Zinc finger protein with KRAB and SCAN domains 12

Molecular Weight

Mass (kDA):
147.866 kDA

Genomic Context


Human

Location:	18q11.2
Sequence:	18; NC_000018.10 (25061924..25352194, complement)

Tissue Specificity

Predominantly expressed in hematopoietic cells. Present in organs and tissues that contain stem and progenitor cells, myeloid and/or lymphoid: placenta, spleen, lymph nodes, thymus, bone marrow and fetal liver. Within the hematopoietic system, it is abundant in CD34(+) cells but undetectable in mature peripheral blood leukocytes, and its levels rapidly decrease during the differentiation of CD34(+) cells in response to hemopoietins.

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Leukemia
Cell Transformation, Neoplastic
Hematopoietic Neoplasms
Acute Lymphocytic Leukemia
Malignant Tumor Of Cervix
Carcinoma
Virus Diseases

Multiple Myeloma
Chromosomal Translocation
Medulloblastoma
L1 Acute Lymphoblastic Leukemia

Pathways

Histone Deacetylation
Gene Silencing
Cell Differentiation
Cell Recognition
Oncogenesis

PTMs

Isopeptide bond

Phosphoprotein

Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ZNF521

References

PMID: 14630787 by Bond H.M., et al. Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells.

PMID: 17344859 by Mullighan C.G., et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia.