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- Table of Contents
Facts about Autophagy-related protein 9A.
Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes.
Human | |
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Gene Name: | ATG9A |
Uniprot: | Q7Z3C6 |
Entrez: | 79065 |
Belongs to: |
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ATG9 family |
APG9 autophagy 9-like 1 (S. cerevisiae); APG9 autophagy 9-like 1; APG9L1APG9-like 1; ATG9 autophagy related 9 homolog A (S. cerevisiae); autophagy 9-like 1 protein; autophagy-related protein 9A; FLJ22169; mATG9; MGD3208
Mass (kDA):
94.447 kDA
Human | |
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Location: | 2q35 |
Sequence: | 2; NC_000002.12 (219219380..219229636, complement) |
Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The starvation-induced redistribution depends on ULK1, ATG13, as well as SH3GLB1.
PMID: 15755735 by Yamada T., et al. Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast.
PMID: 16940348 by Young A.R., et al. Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes.