Aspm Antibodies

AND Aspm ELISA kits, Aspm Proteins

Many biological assays use antibodies to detect Aspm, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Aspm in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Aspm antibodies...

We validate the specificity of these antibodies to Aspm by testing them on tissues known to express Aspm positively and negatively. Browse below to find the Aspm antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Aspm Infographic by Boster Bio

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Anti-ASPM Antibody

Human

IHC

$380
Cat # A02584
100ul

Aspm Overview

Facts about Abnormal spindle-like microcephaly-associated protein homolog.

Abnormal spindle-like microcephaly-associated protein homolog (Aspm)

Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux appear to depend on its association with the katanin complex formed by KATNA1 and KATNB1.

Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end expansion and reversely this function can be improved by the katanin complex (PubMed:28436967).

Gene Information

Mouse
Gene Name:	Aspm
Uniprot:	Q8CJ27
Entrez:	12316

Family

Belongs to:

No superfamily

Alternative Names

asp (abnormal spindle) homolog, microcephaly associated (Drosophila); Asp homolog; ASP; Calmbp1; FLJ43117; MCPH5DKFZp686N06184; microcephaly associated (Drosophila); microcephaly, primary autosomal recessive 5

Molecular Weight

Mass (kDA):
364.218 kDA

Genomic Context


Mouse

Location:	1\|1 E4-F
Sequence:	1;

Tissue Specificity

Expressed in fetal brain, peripheral nervous system, liver and spleen. In the adult, expressed exclusively in testis, ovary and spleen.

Diseases

Microcephaly
Primary Microcephaly
Malignant Neoplasms
Neoplasms
Malignant Paraganglionic Neoplasm
Glioblastoma
Dwarfism
Severe Mental Retardation
Brain Neoplasms
Developmental Disabilities
Medulloblastoma

Congenital Abnormality
Liver Carcinoma
Mental Disorders
Cytogenetic Abnormality
Polymicrogyria
Malignant Neoplasm Of Breast

Pathways

Mitosis
Neurogenesis
Brain Development
Cell Cycle
Cell Division
Cytokinesis
Cell Proliferation
Cognition
Localization
Pathogenesis
Chromosome Segregation
Stem Cell Proliferation
Cell Death

Mitotic Cell Cycle
Immune Response
Hypersensitivity
Spindle Assembly
Dna Repair
Cell Adhesion
Cell Cycle Checkpoint

PTMs

Methylation
Demethylation

Phosphorylation
Cleavage

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Aspm

References

PMID: 12355089 by Bond J., et al. ASPM is a major determinant of cerebral cortical size.

PMID: 15972725 by Kouprina N., et al. The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein.