ASIC2 Antibodies

AND ASIC2 ELISA kits, ASIC2 Proteins

Many biological assays use antibodies to detect ASIC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ASIC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ASIC2 antibodies...

We validate the specificity of these antibodies to ASIC2 by testing them on tissues known to express ASIC2 positively and negatively. Browse below to find the ASIC2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ASIC2 Infographic by Boster Bio

All ASIC2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-ACCN1/ASIC2 Antibody Picoband®

7 Q&As

Human, Rat

$370
Cat # PB10046
100 μg/vial

Anti-ACCN1/ASIC2 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A04055-1
100 μg/vial

ACCN1 (ASIC2) (NM_001094) Human Recombinant Protein

$813
Cat # PROTQ16515
20 µg

ACCN1 (ASIC2) (NM_001094) Human Over-expression Lysate

Human

$628
Cat # LS000040
100 µg

ASIC2 Overview

Facts about Acid-sensing ion channel 2.

ASIC2 3D structure. Source: alphafold

Acid-sensing ion channel 2 (ASIC2)

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+).

Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.

Gene Information

Human
Gene Name:	ASIC2
Uniprot:	Q16515
Entrez:	40

Family

Belongs to:

amiloride-sensitive sodium channel (TC 1.A.6) family

Alternative Names

Acid-sensing ion channel 2; Amiloride-sensitive brain sodium channel; amiloride-sensitive cation channel 1, neuronal; ASIC2a; ASIC2Mammalian degenerin homolog; BNAC1; BNaC1ACCN; BNC1Amiloride-sensitive cation channel neuronal 1; degenerin; hBNaC1; MDEGBrain sodium channel 1; neuronal amiloride-sensitive cation channel 1

Molecular Weight

Mass (kDA):
57.709 kDA

Genomic Context


Human

Location:	17q11.2-q12
Sequence:	17; NC_000017.11 (33013087..34156806, complement)

Tissue Specificity

Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes.

Diseases

Pain
Nervousness
Acidosis
Inflammation
Glioma
Neoplasms
Ischemia
Nerve Degeneration
Pathologic Vasoconstriction
Hyperalgesia
Stenosis
Cardiovascular Diseases

Hypertensive Disease
Hypoxia
Malignant Neoplasms
Dysautonomia
Mental Disorders
Visceral Pain
Neurodegenerative Disorders

Interacting Proteins

PICK1

Pathways

Localization
Cell Migration
Transport
Muscle Cell Migration
Smooth Muscle Cell Migration
Synaptic Transmission
Response To Ph
Reflex
Vasoconstriction
Cell Death
Pathogenesis
Protein Phosphorylation
Osteoclast Differentiation

Proteolysis
Vasculogenesis
Swimming
Chemotaxis
Reverse Transcription
Sensitization
Translation

PTMs

Cleavage

Acetylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ASIC2

References

PMID: 8626462 by Price M.P., et al. Cloning and expression of a novel human brain Na+ channel.

PMID: 8631835 by Waldmann R., et al. The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans.