ARRDC3 Antibodies

AND ARRDC3 ELISA kits, ARRDC3 Proteins

Many biological assays use antibodies to detect ARRDC3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ARRDC3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ARRDC3 antibodies...

We validate the specificity of these antibodies to ARRDC3 by testing them on tissues known to express ARRDC3 positively and negatively. Browse below to find the ARRDC3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ARRDC3 Infographic by Boster Bio

All ARRDC3 Products

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Specificity

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Anti-ARRDC3 Antibody

4 Q&As

Human, Mouse, Rat

$360
Cat # A07177
100 µl

Anti-ARRDC3 Antibody

Human, Mouse, Rat

ELISA, IHC, WB

$380
Cat # A07177-1
100ul

ARRDC3 Overview

Facts about Arrestin domain-containing protein 3.

ARRDC3 3D structure. Source: alphafold

Arrestin domain-containing protein 3 (ARRDC3)

Adapter protein that plays a role in regulating cell- surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). Plays a role in NEDD4-mediated ubiquitination and endocytosis af triggered ADRB2 and following ADRB2 degradation (PubMed:20559325, PubMed:23208550).

May recruit NEDD4 into ADRB2 (PubMed:20559325). Alternatively, may be the adapter protein that doesn't play a major role in recruiting NEDD4 into ADRB2, but rather plays a part in a targeting ADRB2 into endosomes (PubMed:23208550).

Gene Information

Human
Gene Name:	ARRDC3
Uniprot:	Q96B67
Entrez:	57561

Family

Belongs to:

arrestin family

Alternative Names

Arrestin domain-containing protein 3

Molecular Weight

Mass (kDA):
46.395 kDA

Genomic Context


Human

Location:	5q14.3
Sequence:	5; NC_000005.10 (91368631..91383332, complement)

Tissue Specificity

Highly expressed in skeletal muscle, placenta, kidney, lung, liver, blood, adrenal gland, lymph node, mammary gland, thyroid, and trachea (PubMed:16269462, PubMed:21982743). Very low levels in colon, thymus, spleen, small intestine, bladder and bone marrow (PubMed:16269462). Strong expression in differentiated adipocytes compared to preadipocytes (PubMed:16269462). Detected in omental fat and subcutaneous fat tissue (PubMed:21982743).

Subcellular Localizations

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome. Endosome. Early endosome. Associated with plasma membrane, as well as with endosomes and lysosomes during endocytosis (PubMed:16269462, PubMed:23208550, PubMed:20559325).

Interacting Proteins

ADRB2
BAG3
DCUN1D1
HPGDS
ITCH

ITGB4
MORF4L1
OTUB2
STAM2
TNFAIP3

TRIM42
UBE2E2
WWP2

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ARRDC3

References

PMID: 16269462 by Oka S., et al. Thioredoxin-binding protein-2-like inducible membrane protein is a novel vitamin D3 and peroxisome proliferator-activated receptor (PPAR)gamma ligand target protein that regulates PPARgamma signaling.

PMID: 20559325 by Nabhan J.F., et al. Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor.