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ARL6IP1 Antibodies
AND ARL6IP1 ELISA kits, ARL6IP1 Proteins
Many biological assays use antibodies to detect ARL6IP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ARL6IP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ARL6IP1 antibodies...
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ARL6IP1 Overview
Facts about ADP-ribosylation factor-like protein 6-interacting protein 1.
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1)
Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate at a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 likely by decreasing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (By similarity).
Plays a role in the formation and stabilization of endoplasmic reticulum tubules (PubMed:24262037). Negatively regulates apoptosis, possibly by regulating the action of caspase-9 (CASP9).
Gene Information
| Human | |
|---|---|
| Gene Name: | ARL6IP1 |
| Uniprot: | Q15041 |
| Entrez: | 23204 |
Family
| Belongs to: |
|---|
| ARL6ip family |
Alternative Names
ADP-ribosylation factor-like 6 interacting protein 1; ADP-ribosylation factor-like 6 interacting protein; AIP1; Aip-1; apoptotic regulator in the membrane of the endoplasmic reticulum; ARL-6-interacting protein 1; ARL6IPaip-1; ARMER; KIAA0069ADP-ribosylation factor-like protein 6-interacting protein 1
Molecular Weight
Mass (kDA):
23.363 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p12.3 |
| Sequence: | 16; NC_000016.10 (18791667..18801549, complement) |
Tissue Specificity
Expressed in all hematopoietic cell lineages, but the highest level of expression is found in early myeloid progenitor cells. Expressed in brain, bone marrow, thymus and lung. Expressed at low level in liver, kidney and spleen. Not detected in heart.
Subcellular Localizations
Endomembrane system; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum. Predominantly localized to intracytoplasmic membranes. Preferentially localizes at the ER tubules and the edge of the ER sheets, both of which are characterized by a high membrane curvature.
Diseases
- Uterine Cervical Neoplasm
- Malignant Tumor Of Cervix
- Malignant Neoplasms
- Cell Invasion
- Liver Carcinoma
- Craniofacial Abnormalities
- Tissue Adhesions
- Neoplasm Invasiveness
- Crest Syndrome
Interacting Proteins
- ACSF2
- COL4A3BP
- DIABLO
- FXR2
- GAD2
- GOLPH3
- GORASP2
- INPP5K
- MTERF3
- NAPB
Pathways
- Transport
- Cell Death
- Cell Cycle
- Cell Growth
- Cell Migration
- Cell Proliferation
- Proteolysis
- Regulation Of Gene Expression
- Wound Healing
PTMs
- Ribosylation
Research Areas
- Apoptosis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ARL6IP1
bosterbio.com/bosterbio-gene-info-cards/ARL6IP1
References
PMID: 10995579 by Pettersson M., et al. Characterization, chromosomal localization, and expression during hematopoietic differentiation of the gene encoding Arl6ip, ADP- ribosylation-like factor-6 interacting protein (ARL6).
PMID: 12754298 by Lui H.M., et al. ARMER, apoptotic regulator in the membrane of the endoplasmic reticulum, a novel inhibitor of apoptosis.