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- Table of Contents
Facts about ADP-ribosylation factor-like protein 4C.
May be involved in transportation between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 into the plasma membrane in the GDP- bound form.
Human | |
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Gene Name: | ARL4C |
Uniprot: | P56559 |
Entrez: | 10123 |
Belongs to: |
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small GTPase superfamily |
ADP ribosylation factor-like protein 7; ADP-ribosylation factor-like 4C; ADP-ribosylation factor-like 7; ADP-ribosylation factor-like protein 4C; ADP-ribosylation factor-like protein 7; ADP-ribosylation factor-like protein LAK; ARL7; LAK
Mass (kDA):
21.487 kDA
Human | |
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Location: | 2q37.1 |
Sequence: | 2; NC_000002.12 (234493041..234497081, complement) |
Expressed in several tumor cell lines (at protein level). Expressed in lung, brain, leukocytes and placenta.
Cell projection, filopodium. Cell membrane. Cytoplasm.
PMID: 10462049 by Jacobs S., et al. ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal.
PMID: 15147902 by Engel T., et al. ADP-ribosylation factor (ARF)-like 7 (ARL7) is induced by cholesterol loading and participates in apolipoprotein AI-dependent cholesterol export.