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- Table of Contents
Facts about Rho guanine nucleotide exchange factor 4.
The APC-ARHGEF4 complex appears to be involved in cell migration in addition to in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells.
Human | |
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Gene Name: | ARHGEF4 |
Uniprot: | Q9NR80 |
Entrez: | 50649 |
Belongs to: |
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No superfamily |
APC-stimulated guanine nucleotide exchange factor 1; Asef; ASEF1; ASEFAPC-stimulated guanine nucleotide exchange factor; GEF4; KIAA1112; Rho guanine nucleotide exchange factor (GEF) 4; rho guanine nucleotide exchange factor 4; STM6
Mass (kDA):
79.067 kDA
Human | |
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Location: | 2q21.1 |
Sequence: | 2; NC_000002.12 (130836914..131051514) |
Expressed at high levels in the brain, skeletal muscle and testis and at low levels in the kidney, lung, small intestine, ovary and prostate. Expression is aberrantly enhanced in most colorectal tumors.
[Isoform 3]: Cytoplasm. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Associated with membrane ruffles.
PMID: 10873612 by Thiesen S., et al. Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22.
PMID: 10947987 by Kawasaki Y., et al. Asef, a link between the tumor suppressor APC and G-protein signaling.