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- Table of Contents
Facts about Rho guanine nucleotide exchange factor 25.
Links specifically G alpha q/11- coupled receptors to RHOA activation (By similarity). May be an important regulator of processes involved in axon and dendrite formation.
Mouse | |
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Gene Name: | Arhgef25 |
Uniprot: | Q9CWR0 |
Entrez: | 52666 |
Belongs to: |
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No superfamily |
GEFTRAC/CDC42 exchange factor; Guanine nucleotide exchange factor GEFT; p63RhoGEFrho guanine nucleotide exchange factor 25; Rac/Cdc42/Rho exchange factor GEFT; Rho guanine nucleotide exchange factor (GEF) 25; RhoA/RAC/CDC42 exchange factor; RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT
Mass (kDA):
68.262 kDA
Mouse | |
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Location: | 10 D3|10 74.5 cM |
Sequence: | 10; |
Highly expressed in excitable tissues, such as brain, heart and muscle. Elevated expression in hippocampus and cerebellum.
PMID: 12547822 by Guo X., et al. A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration.
PMID: 15322108 by Bryan B., et al. GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation.