This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about DNA dC->dU-editing enzyme APOBEC-3C.
The resultant detrimental levels of mutations from the proviral genome, together with a deamination- independent mechanism which operates prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and doesn't deaminate double-stranded DNA or single-or double- stranded RNA.
Human | |
---|---|
Gene Name: | APOBEC3C |
Uniprot: | Q9NRW3 |
Entrez: | 27350 |
Belongs to: |
---|
cytidine and deoxycytidylate deaminase family |
APOBEC1LA3C; APOBEC1-like; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C; ARDC2; ARDC4; ARP5; bK150C2.3; EC 3.5.4.-; PBIMGC19485; Phorbolin I; probable DNA dC->dU-editing enzyme APOBEC-3C
Mass (kDA):
22.826 kDA
Human | |
---|---|
Location: | 22q13.1 |
Sequence: | 22; NC_000022.11 (39014236..39020352) |
Expressed in spleen, testes, peripherical blood lymphocytes, heart, thymus, prostate and ovary.
Nucleus. Cytoplasm.
PMID: 11863358 by Jarmuz A., et al. An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22.
PMID: 12859895 by Mariani R., et al. Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif.