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- Table of Contents
Facts about C->U-editing enzyme APOBEC-2.
Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Human | |
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Gene Name: | APOBEC2 |
Uniprot: | Q9Y235 |
Entrez: | 10930 |
Belongs to: |
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cytidine and deoxycytidylate deaminase family |
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2; ARCD1; ARP1; EC 3.5.4; EC 3.5.4.-; probable C->U-editing enzyme APOBEC-2
Mass (kDA):
25.703 kDA
Human | |
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Location: | 6p21.1 |
Sequence: | 6; NC_000006.12 (41053201..41064891) |
Expressed exclusively in heart and skeletal muscle.
PMID: 10403781 by Liao W., et al. APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family.
PMID: 21496894 by Guo J.U., et al. Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.