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- Table of Contents
Facts about Apelin.
Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (By similarity). Hormone involved in the regulation of coronary artery cell movements during gastrulation and heart morphogenesis (By similarity).
Human | |
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Gene Name: | APLN |
Uniprot: | Q9ULZ1 |
Entrez: | 8862 |
Belongs to: |
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apelin family |
AGTRL1 ligand; AGTRL1 Lligand; APEL; Apelin; apelin, AGTRL1 ligand; APJ endogenous ligand; APLN; XNPEP2
Mass (kDA):
8.569 kDA
Human | |
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Location: | Xq26.1 |
Sequence: | X; NC_000023.11 (129645259..129654956, complement) |
Expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus and midbrain (PubMed:10617103). Secreted by the mammary gland into the colostrum and the milk.
Secreted. Secreted, extracellular space. Abundantly secreted in the colostrum. Lower level in milk. Decreases rapidly within several days after parturition in milk, but is still detectable even in commercial milk.
PMID: 9792798 by Tatemoto K., et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor.
PMID: 10525157 by Habata Y., et al. Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum.