Apelin Antibodies

Apelin (APLN)

Endogenous ligand for the apelin receptor (APLNR) (PubMed:10525157). Drives internalization of the apelin receptor (By similarity).

Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (By similarity). Hormone involved in the regulation of coronary artery cell movements during gastrulation and heart morphogenesis (By similarity).

Gene Information

Human
Gene Name:	APLN
Uniprot:	Q9ULZ1
Entrez:	8862

Family

Belongs to:
apelin family

Alternative Names

AGTRL1 ligand; AGTRL1 Lligand; APEL; Apelin; apelin, AGTRL1 ligand; APJ endogenous ligand; APLN; XNPEP2

Molecular Weight

Mass (kDA):
8.569 kDA

Genomic Context

Human
Location:	Xq26.1
Sequence:	X; NC_000023.11 (129645259..129654956, complement)

Tissue Specificity

Expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus and midbrain (PubMed:10617103). Secreted by the mammary gland into the colostrum and the milk.

Subcellular Localizations

Secreted. Secreted, extracellular space. Abundantly secreted in the colostrum. Lower level in milk. Decreases rapidly within several days after parturition in milk, but is still detectable even in commercial milk.

Diseases

• Obesity
• Heart Failure
• Tumor Angiogenesis
• Insulin Resistance
• Diabetes Mellitus
• Hypertensive Disease
• Cardiovascular Diseases
• Diabetes Mellitus, Non-insulin-dependent
• Inflammation
• Pathologic Neovascularization
• Nervousness
• Atherosclerosis
• Hypoxia

• Insulin Sensitivity
• Hiv Infections
• Hypertrophy
• Infarction
• Immunologic Deficiency Syndromes
• Myocardial Infarction
• Pituitary Diseases

Pathways

• Angiogenesis
• Secretion
• Pathogenesis
• Cell Proliferation
• Localization
• Glucose Homeostasis
• Vasoconstriction
• Regulation Of Blood Pressure
• Diuresis
• Insulin Secretion
• Lactation
• Regeneration
• Receptor Internalization

• Cellular Localization
• Feeding Behavior
• Vasodilation
• Heart Development
• Neuroprotection
• Cell Migration
• Vasculogenesis

PTMs

• Phosphorylation
• Glycosylation
• Oxidation

• Nitration
• Reduction
• Cleavage

• Acylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/APLN

Boster Bio - Best Uses Of The APLN Marker

This article will provide more details about the Boster bio Low Density Lipoprotein receptor (LDLR), Macrosialin monoclonal antibody, and Macrosialin monoclonal antibody. This article will help in understanding how best to utilize each product. And don't not forget to check out the Boster Microplate Reader review!

Boster Bio: Low Density Lipoprotein Receptor (LDLR) Family

Antibodies against the Low-Density Lipoprotein Receptor (LDR) Family are available in various sizes and types, from monoclonal to polyclonal. They react with LDLR in various animal specimens, including human and rat. The antibodies are produced from single-pass type I membrane proteins, which form clathrin-coated pits upon ligand binding.

Low-Density Lipoprotein Receptors (LDL) are cell surface proteins that participate in endocytosis that is mediated by receptors. They are important in VLDL-triglyceride metabolism and the signaling pathway of the reelin. Some individuals with genetic variants in the LDLR gene have a condition known as familial hypercholesterolemia. Alternative splicing is a process that can result in numerous transcript variants.

The VLDL receptor belongs to the Low-Density Lipoprotein Receptor (VLDL) gene family. It has been cloned in rabbits and humans. The distribution of tissues and the characterization suggest that it could play a role in the transfer of triglycerides to peripheral tissue. Numerous studies of the VLDL receptor's distribution across different tissues have shown that it is present in a variety of organs and tissues including the heart, skeletal muscle, fat, and blood. However, after fasting and refeeding, there were no significant changes were observed.

The Low-Density Lipoprotein Receptor (HDLR) family is comprised of two major subtypes called precursor and mature. The precursor and mature forms are significantly smaller. These receptors have the ability to bind to LDL and are tested for 24 hours after transfection. The levels of a-tubulin were normalized to the relative band intensities of the mature LDLR and the precursor.

Boster Bio: Antibody to Macrosialin CD68

Boster Bio offers a range of antibodies that react with mouse, human and rat apolipoproteinE. The antibodies are tested by a variety of methods. The Boster Anti Caveolin-1 Antibody, catalog no PA1514, is able to react to the sequence of the mouse apolipoprotein E. It is suitable for a variety of research applications.

Boster Bio: Macrosialin Monoclonal Antibody CD86

Anti-Macrosialin CD68 monoclonal antibody was tested in IHC-P, IHC-F applications on mouse rat. The Boster Bio Anti-Macrosialin CD68 Monoclonal Antibody is able to react with human and mouse cells. This product contains trehalose which is an anti-bacterial ingredient.

The Boster Antibody provides highly validated monoclonal antibodies derived from popular clones. It has been recognized for over a quarter of a century and has a high affinity. Additionally, it is available in a variety of conjugates. Customers have to select the conjugate they want to purchase at checkout once they have purchased it. Monoclonal antibodies are beneficial for a variety of applications.

The production process of rabbit monoclonal antibodies includes immunization in plasma cells as well as cloning, screening, and selection. The best clone will be selected to further study and scale up production. Production can take between four to six months. The quality of the antibody can be monitored through testing in the laboratory as well as through the FDA approval process.