APC2 Antibodies

AND APC2 ELISA kits, APC2 Proteins

Many biological assays use antibodies to detect APC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with APC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop APC2 antibodies...

We validate the specificity of these antibodies to APC2 by testing them on tissues known to express APC2 positively and negatively. Browse below to find the APC2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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APC2 Infographic by Boster Bio

All APC2 Products

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Specificity

Applications

Price

Anti-APC2 Antibody Picoband®

6 Q&As

Human

$370
Cat # PB10041
100 μg/vial

Anti-APC2 Antibody

Human, Mouse

ELISA, IF, ICC, WB

$449
Cat # A02624
0.1 mg

APC2 Overview

Facts about Adenomatous polyposis coli protein 2.

APC2 3D structure. Source: alphafold

Adenomatous polyposis coli protein 2 (APC2)

Stabilizes microtubules and might regulate actin fiber dynamics through the activation of Rho family GTPases (PubMed:25753423). May also function in Wnt signaling by encouraging the rapid degradation of CTNNB1 (PubMed:10021369, PubMed:11691822, PubMed:9823329).

Gene Information

Human
Gene Name:	APC2
Uniprot:	O95996
Entrez:	10297

Family

Belongs to:

adenomatous polyposis coli (APC) family

Alternative Names

adenomatosis polyposis coli 2; adenomatous polyposis coli like; adenomatous polyposis coli protein 2; APCL

Molecular Weight

Mass (kDA):
243.949 kDA

Genomic Context


Human

Location:	19p13.3
Sequence:	19; NC_000019.10 (1446268..1473244)

Tissue Specificity

Widely expressed (at protein level). Specifically expressed in the CNS.

Subcellular Localizations

Cytoplasm, cytoskeleton. Golgi apparatus. Cytoplasm. Cytoplasm, perinuclear region. Associated with actin filaments (PubMed:11691822, PubMed:25753423). Associated with microtubule network (PubMed:10644998, PubMed:11691822, PubMed:25753423).

Diseases

Neoplasms
Adenomatous Polyposis Coli
Polyposis
Malignant Neoplasms
Colorectal Neoplasms
Carcinoma
Nervousness
Colorectal Cancer
Tissue Adhesions
Malignant Tumor Of Colon
Malignant Neoplasm Of Lung
Lung Neoplasms

Adenocarcinoma
Carcinogenesis
Cell Transformation, Neoplastic
Adenoma
Polyps
Polyploidy
Microsatellite Instability

Interacting Proteins

MAPRE1
MAPRE3
TP53BP2

Pathways

Cell Cycle
Localization
Anaphase
Mitosis
Metaphase
Cell Division
Cell Proliferation
Methylation
Exit From Mitosis
Interphase
Cell Motility
Stem Cell Division
Chromosome Segregation

Meiosis
G1 Phase
Cell Adhesion
Cell Migration
Centrosome Separation
Cell-cell Adhesion
Oncogenesis

PTMs

Phosphorylation
Ubiquitination

Methylation
Cleavage

Research Areas

Cell Biology
Cell Cycle and Replication
Ubiquitin Proteasome Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/APC2

References

PMID: 9823329 by Nakagawa H., et al. Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin.

PMID: 10551328 by Nakagawa H., et al. Analysis of APCL, a brain-specific adenomatous polyposis coli homologue, for mutations and expression in brain tumors.