Anoctamin-1 Antibodies

AND ANO1 ELISA kits, Anoctamin-1 Proteins

Many biological assays use antibodies to detect Anoctamin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Anoctamin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Anoctamin-1 antibodies...

We validate the specificity of these antibodies to Anoctamin-1 by testing them on tissues known to express ANO1 positively and negatively. Browse below to find the ANO1 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ANO1 Infographic by Boster Bio

All ANO1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-TMEM16A/ANO1 Antibody Picoband®

1 Citations 2 Q&As

Human, Mouse, Rat

$370
Cat # PA2290
100 μg/vial

Anti-TM16A ANO1 Antibody

4 Q&As

Human, Mouse

ELISA, IF, ICC

$335
Cat # A30508
100ul

Anti-TMEM16A/ANO1 Antibody Picoband®

Human

Flow Cytometry, IHC, WB

$370
Cat # A00713
100 μg/vial

Anti-TMEM16A (ANO1) Mouse Monoclonal Antibody [Clone ID: OTI5H7]

Human, Mouse, Rat

IHC, WB

$523
Cat # M00713
100 µl

Anti-TMEM16A Rabbit Monoclonal Antibody

Human

Flow Cytometry, IHC

$370
Cat # M00713-1
100 μl/vial

ANO1 Overview

Facts about Anoctamin-1.

ANO1 3D structure. Source: alphafold

Anoctamin-1 (ANO1)

Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles.

Acts as a major contributor to both basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. .

Gene Information

Human
Gene Name:	ANO1
Uniprot:	Q5XXA6
Entrez:	55107

Family

Belongs to:

anoctamin family

Alternative Names

ANO1; anoctamin 1; DOG1; ORAOV2; TAOS2; TMEM16A

Molecular Weight

Mass (kDA):
114.078 kDA

Genomic Context


Human

Location:	11q13.3
Sequence:	11; NC_000011.10 (69985907..70189530)

Tissue Specificity

Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors.

Diseases

Neoplasms
Gastrointestinal Stromal Tumors
Cystic Fibrosis
Fibrosis
Stromal Neoplasm
Intrahepatic Cholangiocarcinoma
Malignant Neoplasms
Carcinoma
Sarcoma
Synovial Sarcoma
Hypertensive Disease
Neoplasm Metastasis
Gastrointestinal Neoplasms

Edema
Pathologic Vasoconstriction
Adenocarcinoma
Fibroid Tumor
Stomach Neoplasms
Pain
Diarrhea

Pathways

Secretion
Transport
Muscle Contraction
Smooth Muscle Contraction
Localization
Cell Proliferation
Ion Transport
Membrane Depolarization
Vasoconstriction
Fluid Transport
Chloride Transport
Peristalsis
Pathogenesis

Fertilization
Cell Cycle
Anion Transport
Iodide Transport
Muscle Cell Proliferation
Cell Activation
Cell Migration

PTMs

Phosphorylation

Biotinylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ANO1

References

PMID: 16906560 by Huang X., et al. Comprehensive genome and transcriptome analysis of the 11q13 amplicon in human oral cancer and synteny to the 7F5 amplicon in murine oral carcinoma.

PMID: 12739008 by Katoh M., et al. FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products.

1 Publications of Boster Anoctamin-1 Antibodies & ELISA Kits

PubMed ID: 10.1096/fasebj.2020.34.s1.06115, Intestinal TMEM16A function as a luminal chloride channel

*More publications can be found for each product on its corresponding product page