Als2cl Antibodies

AND Als2cl ELISA kits, Als2cl Proteins

Many biological assays use antibodies to detect Als2cl, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Als2cl in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Als2cl antibodies...

We validate the specificity of these antibodies to Als2cl by testing them on tissues known to express Als2cl positively and negatively. Browse below to find the Als2cl antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Als2cl Infographic by Boster Bio

All Als2cl Products

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Product

Figures

Specificity

Applications

Price

ALS2CL (NM_182775) Human Recombinant Protein

$813
Cat # PROTQ60I27
20 µg

ALS2CL (NM_182775) Human Over-expression Lysate

Human

$628
Cat # LS259173
100 µg

Als2cl Overview

Facts about ALS2 C-terminal-like protein.

ALS2 C-terminal-like protein (Als2cl)

Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics (By similarity).

Gene Information

Mouse
Gene Name:	Als2cl
Uniprot:	Q60I26
Entrez:	235633

Family

Belongs to:

No superfamily

Alternative Names

ALS2 C-terminal like; ALS2 C-terminal-like protein; DKFZp686I0110; DKFZp686P238; FLJ36525; MGC129698; RN49018

Molecular Weight

Mass (kDA):
108.146 kDA

Genomic Context


Mouse

Location:	9 F2\|9 60.79 cM
Sequence:	9;

Tissue Specificity

Expressed in heart, lung, liver and kidney.

Diseases

Motor Neuron Disease
Amyotrophic Lateral Sclerosis
Sclerosis
Primary Lateral Sclerosis
Cell Transformation, Neoplastic
Malignant Squamous Cell Neoplasm
Hereditary Diseases
Nerve Degeneration
Head And Neck Carcinoma
Nervous System Disorder
Autoimmune Diseases
Carcinoma

Head And Neck Neoplasms
Corneal Diseases
Malignant Neoplasms
Conjunctival Diseases
Blepharitis
Genetic Diseases, Inborn

Pathways

Cell Activation
Microglial Cell Activation
Neuron Death
Tear Secretion
Secretion

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Als2cl

References

PMID: 12140191 by Mitchem K.L., et al. Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6.

PMID: 15388334 by Hadano S., et al. ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics.