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- Table of Contents
Facts about Arachidonate 12-lipoxygenase, 12S-type.
Has a dual activity since it also converts leukotriene A4/LTA4 into the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it modulates distinct biological processes including platelet activation.
Human | |
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Gene Name: | ALOX12 |
Uniprot: | P18054 |
Entrez: | 239 |
Belongs to: |
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lipoxygenase family |
12(S)-lipoxygenase; 12-LOX; 12S-lipoxygenase; 12S-LOXarachidonate 12-lipoxygenase, 12S-type; arachidonate 12-lipoxygenase; EC 1.13.11; EC 1.13.11.31; LOG12; platelet 12-LOX; platelet-type 12-lipoxygenase; Platelet-type lipoxygenase 12
Mass (kDA):
75.694 kDA
Human | |
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Location: | 17p13.1 |
Sequence: | 17; NC_000017.11 (6993791..7010754) |
Expressed in vascular smooth muscle cells.
Cytoplasm, cytosol. Membrane. Membrane association is stimulated by EGF.
PMID: 2244907 by Yoshimoto T., et al. Molecular cloning and expression of human arachidonate 12- lipoxygenase.
PMID: 2377602 by Funk C.D., et al. Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase.