ALG8 Antibodies

AND ALG8 ELISA kits, ALG8 Proteins

Many biological assays use antibodies to detect ALG8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ALG8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ALG8 antibodies...

We validate the specificity of these antibodies to ALG8 by testing them on tissues known to express ALG8 positively and negatively. Browse below to find the ALG8 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ALG8 Infographic by Boster Bio

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ALG8 (NM_024079) Human Over-expression Lysate

Human

$628
Cat # LS079053
100 µg

ALG8 Overview

Facts about Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase.

ALG8 3D structure. Source: alphafold

Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (ALG8)

Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol before it's transferred to the nascent peptide (By similarity).

Required for PKD1/Polycystin-1 maturation and localization to the plasma membrane of the main cilia (By similarity). .

Gene Information

Human
Gene Name:	ALG8
Uniprot:	Q9BVK2
Entrez:	79053

Family

Belongs to:

ALG6/ALG8 glucosyltransferase family

Alternative Names

alpha-1,3-glucosyltransferase); asparagine-linked glycosylation 8 homolog (S. cerevisiae; asparagine-linked glycosylation 8 homolog (yeast; asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S.cerevisiae); Asparagine-linked glycosylation protein 8 homolog; CDG1H; dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase; dolichyl-P-glucose:Glc1Man9GlcNAc2-PP-dolichyl-alpha-1,3-glucosyltransferase; EC 2.4.1; EC 2.4.1.-; HUSSY-02; MGC2840; probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-gl

Molecular Weight

Mass (kDA):
60.088 kDA

Genomic Context


Human

Location:	11q14.1
Sequence:	11; NC_000011.10 (78100942..78139653, complement)

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Congenital Disorders Of Glycosylation
Congenital Disorders
Optic Atrophy
Liver Diseases
Cystic Fibrosis
Neoplasm Metastasis
Oligohydramnios
Malignant Neoplasm Of Breast
Ataxia
Lung Diseases
Intestinal Diseases
Variable Number Tandem Repeat

Edema
Fibrosis
Malignant Neoplasms
Hemorrhage
Neoplasms
Alveolar Soft Part Sarcoma
Nervousness

Pathways

Glycosylation
Translation
Protein Glycosylation
Localization
Transport
Cell Division
Fermentation
Cell Growth
Regulation Of Gene Expression

Membrane Fusion
Secretion
Cytokinesis

PTMs

Glycosylation

Nitration

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ALG8

References

PMID: 11124703 by Stanchi F., et al. Characterization of 16 novel human genes showing high similarity to yeast sequences.

PMID: 12480927 by Chantret I., et al. A deficiency in dolichyl-P-glucose:Glc1Man9GlcNAc2-PP-dolichyl alpha3-glucosyltransferase defines a new subtype of congenital disorders of glycosylation.