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- Table of Contents
Facts about Delta-1-pyrroline-5-carboxylate synthase.
Human | |
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Gene Name: | ALDH18A1 |
Uniprot: | P54886 |
Entrez: | 5832 |
Belongs to: |
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No superfamily |
aldehyde dehydrogenase 18 family, member A1; Aldehyde dehydrogenase family 18 member A1; delta-1-pyrroline-5-carboxylate synthase; EC 2.1.2.11; EC 2.3.3.13; GSASdelta1-pyrroline-5-carboxlate synthetase; MGC117316; P5CSdelta-1-pyrroline-5-carboxylate synthetase; PYCSEC 1.2.1.41; pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase)
Mass (kDA):
87.302 kDA
Human | |
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Location: | 10q24.1 |
Sequence: | 10; NC_000010.11 (95605938..95656901, complement) |
Mitochondrion inner membrane.
ALDh28A1 is an cellular nutrient that regulates the release of a hormone called, glucocorticoids. It regulates certain proteins in the body such as leucine and thiamine. This gene is also known sdc1 (NM_001278426.3).
SDC1 is an endocrine-associated, novel cancer gene. It acts as a coreceptor of cytokines. It regulates many important biological process in BC cells including cell proliferation, adhesion and migration. In BC, high levels of SDC1 are associated with poor prognosis, reduced overall survival, and resistance to chemotherapy. Interestingly, high levels SDC1 have been associated with decreased ER expression in aggressive or inflammatory BC subtypes. This gene may also activate the NFkB pathway.
One of many things that the ALDh28A1 Gene can do is control the function T cells. The ALDh28A1 gene, which is expressed by T cells, is associated with their function. It can also help detect immune cells that have stopped working properly. This gene affects IL33 and Ccl9 genes, Klrd1, IL22/IL7R, IL21, IL22, IL22, IL22, IL22, IL22, IL22, IL22, IL21.
Steve Boster's life was filled with events that shaped the course of his career. As a manager of retail sales, he helped people realize their dreams for decades. He was also a U.S. Army veteran and a Concordia Hall member in Staunton, Virginia. Boster leaves behind Nina Mae, his wife, and two daughters, Natosha Paeck and Crystal Boster. His siblings Tammy and Jack Boster, as well as sister Sandra Blanton, are his other family members. His son Jonathan, and grandson Cory (both of Herrin, IL) are his survivors.
Steve Boster's 1993 first product was created. He later developed hundreds of primary antibodies and different products for IHC. His company had grown to one of China's most important catalog antibody companies by the late 1990s. PicoKine(tm), a patented ELISA system, was developed by him. This platform delivers high-sensitivity ELISA test kits that are used to diagnose disease.
PMID: 8761662 by Aral B., et al. Database cloning human delta 1-pyrroline-5-carboxylate synthetase (P5CS) cDNA: a bifunctional enzyme catalyzing the first 2 steps in proline biosynthesis.
PMID: 10037775 by Hu C.A., et al. Molecular enzymology of mammalian delta1-pyrroline-5-carboxylate synthase. Alternative splice donor utilization generates isoforms with different sensitivity to ornithine inhibition.