AKR1C2 Antibodies

AND AKR1C2 ELISA kits, AKR1C2 Proteins

Many biological assays use antibodies to detect AKR1C2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AKR1C2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AKR1C2 antibodies...

We validate the specificity of these antibodies to AKR1C2 by testing them on tissues known to express AKR1C2 positively and negatively. Browse below to find the AKR1C2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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AKR1C2 Infographic by Boster Bio

All AKR1C2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-AKR1C1/C2 Antibody Picoband®

6 Q&As

Human, Mouse, Rat

Flow Cytometry, IF, ICC, WB

$370
Cat # PB10036
100 μg/vial

Anti-DD2 AKR1C2 Antibody

Human

ELISA, IHC, WB

$380
Cat # A02661
100ul

AKR1C2 (NM_205845) Human Recombinant Protein

$1062
Cat # PROTP52895
20 µg

AKR1C2 (NM_001354) Human Over-expression Lysate

Human

$628
Cat # LS001646
100 µg

AKR1C2 Overview

Facts about Aldo-keto reductase family 1 member C2.

AKR1C2 3D structure. Source: alphafold

Aldo-keto reductase family 1 member C2 (AKR1C2)

Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones to the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha- DHT) into 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol).

Has a top bile-binding ability. .

Gene Information

Human
Gene Name:	AKR1C2
Uniprot:	P52895
Entrez:	1646

Family

Belongs to:

aldo/keto reductase family

Alternative Names

aldo-keto reductase family 1 member C2; aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acidbinding protein; 3-alpha hydroxysteroid dehydrogenase, type III); BABP; Chlordecone reductase homolog HAKRD; DD; DD-2; DD2DD/BABP; DDH2FLJ53800; Dihydrodiol dehydrogenase 2; Dihydrodiol dehydrogenase/bile acid-binding protein; EC 1.1.1,3-alpha-HSD3; EC 1.1.1.213; EC 1.3.1.20; HAKRDAKR1C-pseudo; HBAB; MCDR2; pseudo-chlordecone reductase; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type II dihydrodiol dehydrogenase; Type III 3-alpha-hydroxysteroid dehydrogenase

Molecular Weight

Mass (kDA):
36.735 kDA

Genomic Context


Human

Location:	10p15.1
Sequence:	10; NC_000010.11 (4987775..5018033, complement)

Tissue Specificity

Expressed in fetal testes. Expressed in fetal and adult adrenal glands.

Subcellular Localizations

Cytoplasm.

Diseases

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Prostate
Malignant Neoplasm Of Breast
Carcinoma
Prostatic Neoplasms
Cholestasis
Liver Carcinoma
Mammary Neoplasms
Adenocarcinoma
Obesity
Malignant Tumor Of Colon
Carcinogenesis

Hypercholesterolemia
Ductal Breast Carcinoma
Lung Neoplasms
Malignant Neoplasm Of Lung
Hyperplasia
Endometriosis, Site Unspecified
Intrahepatic Cholestasis

Pathways

Transport
Secretion
Cell Proliferation
Localization
Excretion
Conjugation
Drug Resistance
Intracellular Transport
Parturition
Pathogenesis
Cholesterol Homeostasis
Intestinal Absorption
Cell Cycle

Anion Transport
Lipid Binding
Ovulation
Cell Death
Cell Adhesion
Glycosylation
Regeneration

PTMs

Phosphorylation
Reduction
Cleavage

Oxidation
Carboxylation
Hydroxylation

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AKR1C2

References

PMID: 8274401 by Qin K.-N., et al. Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.

PMID: 8011662 by Ciaccio P.J., et al. cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase.