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- Table of Contents
Facts about A-kinase anchor protein 13.
May also activate other Rho family members (PubMed:11546812). Section of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597, PubMed:21224381).
Human | |
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Gene Name: | AKAP13 |
Uniprot: | Q12802 |
Entrez: | 11214 |
Belongs to: |
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No superfamily |
A kinase (PRKA) anchor protein 13; AKAP-LbcAKAP-13; A-kinase anchor protein 13; A-kinase anchoring protein; ARHGEF13; Breast cancer nuclear receptor-binding auxiliary protein; BRXNon-oncogenic Rho GTPase-specific GTP exchange factor; c-lbc; FLJ11952; FLJ43341; Guanine nucleotide exchange factor Lbc; HA-3; HT31; Human thyroid-anchoring protein 31; LBCLBC oncogene; Lymphoid blast crisis oncogeneProtein kinase A-anchoring protein 13; p47; PROTO-LB; PROTO-LBC
Mass (kDA):
307.55 kDA
Human | |
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Location: | 15q25.3 |
Sequence: | 15; NC_000015.10 (85380603..85749358) |
Detected in mammary gland (PubMed:9627117). Detected in heart (at protein level) (PubMed:11546812). Expressed as a 5.3 kb transcript in hematopoietic cells, skeletal muscle, lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Predominantly expressed as a 10 kb transcript in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver. Transcripts of between 6-9 kb are also expressed in myeloid and lymphoid lineages, a variety of epithelial tissues, and in skeletal muscle.
Cytoplasm, cytosol. Cytoplasm. Cytoplasm, cell cortex. Nucleus. Membrane; Peripheral membrane protein. Colocalizes with the actin cytoskeleton at the cell cortex.
PMID: 11696353 by Klussmann E., et al. Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling.
PMID: 11546812 by Diviani D., et al. AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation.