Autoimmune regulator Antibodies

AND AIRE ELISA kits, Autoimmune regulator Proteins

Many biological assays use antibodies to detect Autoimmune regulator, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Autoimmune regulator in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Autoimmune regulator antibodies...

We validate the specificity of these antibodies to Autoimmune regulator by testing them on tissues known to express AIRE positively and negatively. Browse below to find the AIRE antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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AIRE Infographic by Boster Bio

All AIRE Products

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Product

Figures

Specificity

Applications

Price

Anti-AIRE Antibody Picoband®

3 Q&As

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # PB9980
100 μg/vial

Anti-AIRE/Aire 1 Antibody

Human, Mouse

IF, WB

$360
Cat # A00558
100 µl

AIRE Colorimetric Cell-Based ELISA Kit

Human, Mouse

ELISA

$480
Cat # EKC1020
1 kit, containing one 96-well plate and all necessary reagents

AIRE (Phospho-Ser156) Colorimetric Cell-Based ELISA Kit

Human

ELISA

$540
Cat # EKC2603
1 kit, containing two 96-well plates and all necessary reagents

Anti-AIRE (P126) Antibody

Human, Mouse, Rat

IF, IHC, WB

$405
Cat # A00558-3
100ul

Anti-Phospho-AIRE-1 (S156) Antibody

Human

ELISA, WB

$380
Cat # A00558S156
100ul

AIRE Overview

Facts about Autoimmune regulator.

Autoimmune regulator (AIRE)

Transcription factor playing an essential role to advertise self-tolerance from the thymus by regulating the expression of a wide selection of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (PubMed:26084028). Binds to G-doublets in an A/T-rich surroundings; the preferred theme is a tandem repeat of 5'-ATTGGTTA-3' combined with a 5'-TTATTA-3' box.

Binds into nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated in'Lys-4', not phosphorylated in'Thr-3' rather than methylated in'Arg-2'.

Gene Information

Human
Gene Name:	AIRE
Uniprot:	O43918
Entrez:	326

Family

Belongs to:

No superfamily

Alternative Names

AIRE; APECED protein; APECED; APECEDAPSI; APS1; APSI; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; autoimmune regulator (APECED protein)10APS1AIRE1; autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermaldystrophy); Autoimmune Regulator; PGA1

Molecular Weight

Mass (kDA):
57.727 kDA

Genomic Context


Human

Location:	21q22.3
Sequence:	21; NC_000021.9 (44285876..44298648)

Tissue Specificity

Widely expressed. Expressed at higher level in thymus (medullary epithelial cells and monocyte-dendritic cells), pancreas, adrenal cortex and testis. Expressed at lower level in the spleen, fetal liver and lymph nodes. In secondary lymphoid organs, expressed in a discrete population of bone marrow-derived toleregenic antigen presenting cells (APCs) called extrathymic AIRE expressing cells (eTAC)(at protein level) (PubMed:23993652). Isoform 2 and isoform 3 seem to be less frequently expressed than isoform 1, if at all.

Subcellular Localizations

Nucleus. Cytoplasm. Predominantly nuclear but also cytoplasmic (PubMed:11274163, PubMed:14974083). Found in nuclear body-like structures (dots) and in a filamentous vimentin-like pattern (PubMed:11274163, PubMed:14974083, PubMed:26084028). Associated with tubular structures (PubMed:11274163, PubMed:14974083).