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- Table of Contents
4 Citations 16 Q&As
3 Citations 5 Q&As
3 Citations 4 Q&As
Facts about Apoptosis-inducing factor 1, mitochondrial.
The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e.
Human | |
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Gene Name: | AIFM1 |
Uniprot: | O95831 |
Entrez: | 9131 |
Belongs to: |
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FAD-dependent oxidoreductase family |
AIF; AIFapoptosis-inducing factor 1, mitochondrial; AIFM1; apoptosis-inducing factor, mitochondrion-associated, 1; COXPD6; MGC111425; PDCD8; PDCD8striatal apoptosis-inducing factor; programmed cell death 8 (apoptosis-inducing factor); Programmed cell death protein 8
Mass (kDA):
66.901 kDA
Human | |
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Location: | Xq26.1 |
Sequence: | X; NC_000023.11 (130129362..130165887, complement) |
Detected in muscle and skin fibroblasts (at protein level). Isoform 5 is frequently down-regulated in human cancers.
Mitochondrion intermembrane space. Mitochondrion inner membrane. Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis (PubMed:1577597
PMID: 9989411 by Susin S.A., et al. Molecular characterization of mitochondrial apoptosis-inducing factor.
PMID: 16365034 by Delettre C., et al. AIFsh, a novel apoptosis-inducing factor (AIF) pro-apoptotic isoform with potential pathological relevance in human cancer.
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