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- Table of Contents
Facts about Aryl hydrocarbon receptor repressor.
Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its XRE site.
Mouse | |
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Gene Name: | Ahrr |
Uniprot: | Q3U1U7 |
Entrez: | 11624 |
Belongs to: |
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No superfamily |
Aryl hydrocarbon receptor repressor
Mass (kDA):
77.726 kDA
Mouse | |
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Location: | 13|13 C1 |
Sequence: | 13; |
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The AHRR Gene is a tumor suppressor that is expressed in a low amount in the gallbladder. The AHRR marker might be useful in diagnosing gallbladder disease. Researchers recently discovered that low levels AHRR are associated to increased gallbladder carcinoma risk. The AHRR Gene is expressed in a wide range tissues, including the Gallbladder.
Methylation of AHRR has been associated with many negative outcomes, including cardiovascular and cancer mortality. Additionally, the methylation status might play a role when these diseases are possible. This marker has many uses and its development will make smoking cessation research and treatment easier. Its methylation status serves as a biomarker that can be used to monitor smoking cessation progress.
The lncRNA, AHRR, is expressed within the nucleus of eukaryotes. This gene is implicated in a variety biochemical processes. Genomic annotation of lncRNA transcripts has been extensive. These have been described for their subcellular localization and cell to-cell variability. However, the patterns of their localization remain largely unresolved. Single-molecule visualizations are crucial for accurate characterization.
To visualize the distribution of lncRNAs in hela cells, we first characterized their cellular localization. These lncRNAs then were classified according to their types of cellular location. The lncRNA-cell pair was then assigned to one the four classes I-V. The magenta star represents five lncRNAs, which are co-located with different cell types and class. The scale bar refers to the top left picture, and is used as a reference to the mRNA set.
Six lncRNA signatures were associated with disease-free survival. These findings indicate that a specific six-lncRNA signature may be useful as a prognostic tool for patients with BRCA. This marker could be used to predict the prognosis and help with individualized treatment. It could also help to predict the effectiveness of tamoxifen therapy in BRCA patients.
The AHRR Gene may be a therapeutic target for immuno-related lncRNAs. Researchers can identify these molecules and target tumors with specific therapeutic therapies. They also found that these lncRNAs strongly associate with AHRR in BRCA patients. These findings are a first step in understanding the biological role and role of immune-related lncRNAs. However, more research is needed to determine their role in AHRR.
The data in the OC RNA datasets were processed to select the top 2,500 lncRNA and mRNA expression modules. Langfelder & Horvath created the WGCNAR package to visualize the gene co-expression module. The TCGA dataset was used by the researchers to identify lncRNAs that are associated with OC immune modulation.
Using qRT-PCR to detect lncRNA-protein interactions was a viable method for detecting AHRR. However, there was a major limitation to this approach. The probes did not detect AHRR. Also, the Northern blots were poor quality. DNA probes can also amplify the RNA-protein complex. To overcome this, researchers could re-design their assays to detect the AHRR gene.
Labelling the lncRNA was very simple. The probes were biotinylated using a BioPrime kit. To label the probes the biotinylated nitides were added separately into the dNTP solution. The kit can be kept in an airtight plastic container for up to one year.
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PMID: 9887096 by Mimura J., et al. Identification of a novel mechanism of regulation of Ah (dioxin) receptor function.
PMID: 12520768 by Huang P., et al. Constitutive and TCDD-induced expression of Ah receptor-responsive genes in the pituitary.