Adenylate cyclase type 8 Antibodies

AND ADCY8 ELISA kits, Adenylate cyclase type 8 Proteins

Many biological assays use antibodies to detect Adenylate cyclase type 8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Adenylate cyclase type 8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Adenylate cyclase type 8 antibodies...

We validate the specificity of these antibodies to Adenylate cyclase type 8 by testing them on tissues known to express ADCY8 positively and negatively. Browse below to find the ADCY8 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ADCY8 Infographic by Boster Bio

All ADCY8 Products

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Anti-ADCY8/Adenylate Cyclase 8 Antibody

3 Q&As

Human, Mouse, Rat

ELISA, IF, IHC-P, ICC

$335
Cat # A08061-1
100ul

ADCY8 (NM_001115) Human Over-expression Lysate

Human

$960
Cat # LS000114
100 µg

ADCY8 Overview

Facts about Adenylate cyclase type 8.

ADCY8 3D structure. Source: alphafold

Adenylate cyclase type 8 (ADCY8)

Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that influence processes suche as synaptic plasticity and insulin secretion. Plays a role in several brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) via CREB transcription factor activity modulation.

Plays a central role in insulin secretion by controlling glucose homeostasis via glucagon-like peptide 1 and sugar signaling pathway and keeps insulin secretion via calcium-dependent PKA activation resulting in vesicle pool replenishment. Additionally, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells.

Gene Information

Human
Gene Name:	ADCY8
Uniprot:	P40145
Entrez:	114

Family

Belongs to:

adenylyl cyclase class-4/guanylyl cyclase family

Alternative Names

AC8; ADCY3; adenylate cyclase 8 (brain); adenylate cyclase type 8; Adenylate cyclase type VIII; Adenylyl cyclase 8; adenylyl cyclase-8, brain; ATP pyrophosphate-lyase 8; Ca(2+)/calmodulin-activated adenylyl cyclase; EC 4.6.1.1; HBAC1

Molecular Weight

Mass (kDA):
140.122 kDA

Genomic Context


Human

Location:	8q24.22
Sequence:	8; NC_000008.11 (130780300..131041604, complement)

Tissue Specificity

Detected in brain cortex (PubMed:1715695). Expressed in islet (PubMed:25403481).

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Apical cell membrane. Cell junction, synapse. Cell projection, dendrite. Cell projection, axon. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic density. Membrane raft. Membrane, coated pit. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane, caveola. Localized to dendritic arbors (By similarity). Monomeric N-glycosylated species localizes in membrane raft. In contrast, monomeric unglycosylated forms are enriched in clathrin-coated pits and vesicles. Dimers are also locali