Adenylate cyclase type 8 Antibodies

Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that influence processes suche as synaptic plasticity and insulin secretion. Plays a role in several brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) via CREB transcription factor activity modulation.

Plays a central role in insulin secretion by controlling glucose homeostasis via glucagon-like peptide 1 and sugar signaling pathway and keeps insulin secretion via calcium-dependent PKA activation resulting in vesicle pool replenishment. Additionally, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells.