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- Table of Contents
Facts about Adenylate cyclase type 3.
Required for the perception of odorants. Required for normal sperm motility and normal male fertility.
Human | |
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Gene Name: | ADCY3 |
Uniprot: | O60266 |
Entrez: | 109 |
Belongs to: |
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adenylyl cyclase class-4/guanylyl cyclase family |
AC3EC 4.6.1.1; AC-III; adenylate cyclase 3; adenylate cyclase type 3; Adenylate cyclase type III; Adenylyl cyclase 3; adenylyl cyclase, type III; ATP pyrophosphate-lyase 3; EC 4.6.1; KIAA0511; olfactive type
Mass (kDA):
128.96 kDA
Human | |
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Location: | 2p23.3 |
Sequence: | 2; NC_000002.12 (24819169..24920237, complement) |
Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, heart, kidney, liver, lung, pancreas islets, placenta, and skeletal muscle (PubMed:9920776). Detected in testis (PubMed:15705663).
Cell membrane; Multi-pass membrane protein. Cytoplasm. Cell projection, cilium. Golgi apparatus. Also detected in the cytoplasm, close to lipid droplets.
PMID: 9920776 by Yang B., et al. Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets.
PMID: 8476432 by Hellevuo K., et al. A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line.