Adenylate cyclase type 10 Antibodies

AND ADCY10 ELISA kits, Adenylate cyclase type 10 Proteins

Many biological assays use antibodies to detect Adenylate cyclase type 10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Adenylate cyclase type 10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Adenylate cyclase type 10 antibodies...

We validate the specificity of these antibodies to Adenylate cyclase type 10 by testing them on tissues known to express ADCY10 positively and negatively. Browse below to find the ADCY10 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ADCY10 Infographic by Boster Bio

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ADCY10 Overview

Facts about Adenylate cyclase type 10.

ADCY10 3D structure. Source: alphafold

Adenylate cyclase type 10 (ADCY10)

Catalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed:15659711, PubMed:24616449, PubMed:25040695, PubMed:24567411). May be the sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (PubMed:15659711, PubMed:17591988).

Has a crucial role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo before fertilization (By similarity).

Gene Information

Human
Gene Name:	ADCY10
Uniprot:	Q96PN6
Entrez:	55811

Family

Belongs to:

adenylyl cyclase class-4/guanylyl cyclase family

Alternative Names

adenylate cyclase 10 (soluble); Adenylate cyclase homolog; adenylate cyclase type 10; AH-related protein; ATP pyrophosphate-lyase; EC 4.6.1.1; Germ cell soluble adenylyl cyclase; HCA2RP1-313L4.2; hsAC; sAC; SAC3'-5'-cyclic AMP synthetase; SACI; Sacy; testicular soluble adenylyl cyclase (SAC); Testicular soluble adenylyl cyclase

Molecular Weight

Mass (kDA):
187.149 kDA

Genomic Context


Human

Location:	1q24.2
Sequence:	1; NC_000001.11 (167809080..167916389, complement)

Tissue Specificity

Detected in airway epithelial cells and testis (at protein level) (PubMed:17591988). Weakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial cells, duodenum, jejunum and ileum. Very low level of expression in bone.

Subcellular Localizations

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Nucleus. Cell projection, cilium. Cytoplasm. Mitochondrion. Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin.

Diseases

Optic Nerve Injuries
Physiological Stress

Pathways

Rna Interference

PTMs

Cleavage

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ADCY10

References

PMID: 11423534 by Jaiswal B.S., et al. Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase.

PMID: 11932268 by Reed B.Y., et al. Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density.