ADAMTS12 Antibodies

AND ADAMTS12 ELISA kits, ADAMTS12 Proteins

Many biological assays use antibodies to detect ADAMTS12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ADAMTS12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ADAMTS12 antibodies...

We validate the specificity of these antibodies to ADAMTS12 by testing them on tissues known to express ADAMTS12 positively and negatively. Browse below to find the ADAMTS12 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ADAMTS12 Infographic by Boster Bio

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Anti-ADAMTS-12 Antibody

Human

ELISA, IHC

$380
Cat # A07159
100ul

ADAMTS12 Overview

Facts about A disintegrin and metalloproteinase with thrombospondin motifs 12.

ADAMTS12 3D structure. Source: alphafold

A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAMTS12)

Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan.

Has anti-tumorigenic properties. .

Gene Information

Human
Gene Name:	ADAMTS12
Uniprot:	P58397
Entrez:	81792

Family

Belongs to:

No superfamily

Alternative Names

A disintegrin and metalloproteinase with thrombospondin motifs 12; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 12; ADAM metallopeptidase with thrombospondin type 1 motif, 12; ADAM-TS 12; ADAM-TS12; ADAMTS-12; EC 3.4.24; EC 3.4.24.-; EC 3.4.24.82; PRO4389

Molecular Weight

Mass (kDA):
177.676 kDA

Genomic Context


Human

Location:	5p13.3-p13.2
Sequence:	5; NC_000005.10 (33523535..33892180, complement)

Tissue Specificity

Expressed in skeletal muscle and fat. Detected at significant levels in fetal lung. Widely expressed in gastric carcinomas and in cancer cells of diverse origin.

Subcellular Localizations

Secreted, extracellular space, extracellular matrix.

Diseases

Malignant Neoplasms
Arthritis
Rheumatoid Arthritis
Degenerative Polyarthritis
Carcinoma
Neoplasms
Cell Invasion
Neoplasm Metastasis
Tumor Progression
Neoplasms, Experimental
Immunologic Deficiency Syndromes
Fracture

Tumor Angiogenesis
Asthma
Pathologic Neovascularization
Bronchial Hyperreactivity
Malignant Paraganglionic Neoplasm
Tissue Adhesions
Inflammation

Interacting Proteins

COMP
Comp
MEOX2
MYL6

Pathways

Localization
Tissue Remodeling
Angiogenesis
Pathogenesis
Cell Adhesion
Regulation Of Chondrocyte Differentiation
Regulation Of Cell Adhesion
Chondrocyte Differentiation
Cartilage Development
Tissue Development

Reverse Transcription
Coagulation
Cellular Localization
Sex Differentiation
Gonad Development

PTMs

Cleavage

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ADAMTS12

References

PMID: 11279086 by Cal S., et al. Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats.

PMID: 16611630 by Liu C.-J., et al. ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein.