ACOX1 Antibodies

AND ACOX1 ELISA kits, ACOX1 Proteins

Many biological assays use antibodies to detect ACOX1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ACOX1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ACOX1 antibodies...

We validate the specificity of these antibodies to ACOX1 by testing them on tissues known to express ACOX1 positively and negatively. Browse below to find the ACOX1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ACOX1 Infographic by Boster Bio

All ACOX1 Products

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Specificity

Applications

Price

Anti-ACOX1 Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$405
Cat # A03054
100ul

Anti-ACOX1 Antibody

Human

IF, IHC-P, WB

$299
Cat # M03054
80 µl

ACOX1 Overview

Facts about Peroxisomal acyl-coenzyme A oxidase 1.

ACOX1 3D structure. Source: alphafold

Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1)

Catalyzes the desaturation of acyl-CoAs into 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length.

Isoform 2 is active against a much broader range of substrates and reveals activity towards quite long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 from 16-hydroxy- palmitoyl-CoA and is 25% more active from 1,16-hexadecanodioyl- CoA.

Gene Information

Human
Gene Name:	ACOX1
Uniprot:	Q15067
Entrez:	51

Family

Belongs to:

acyl-CoA oxidase family

Alternative Names

ACOXEC 1.3.3.6; acyl-CoA oxidase 1, palmitoyl; acyl-CoA oxidase, straight-chain; acyl-Coenzyme A oxidase 1, palmitoyl; AOX; PALMCOX; Palmitoyl-CoA oxidase; peroxisomal acyl-coenzyme A oxidase 1; peroxisomal fatty acyl-CoA oxidase; SCOXMGC1198; Straight-chain acyl-CoA oxidase

Molecular Weight

Mass (kDA):
74.424 kDA

Genomic Context


Human

Location:	17q25.1
Sequence:	17; NC_000017.11 (75941507..75979199, complement)

Tissue Specificity

Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tissue and testis. Levels are almost equal in heart.

Subcellular Localizations

Peroxisome.

Diseases

Obesity
Liver Carcinoma
Steatohepatitis
Carcinoma
Malignant Neoplasms
Peroxisomal Disorders
Adrenoleukodystrophy
Fatty Liver
Steatosis
Inflammation
Liver Neoplasms
Atherosclerosis

Peroxisomal Acyl-coa Oxidase Deficiency
Insulin Sensitivity
Diabetes Mellitus
Hepatomegaly
Neurodegenerative Disorders
Malignant Neoplasm Of Liver
Carcinogenesis

Pathways

Fatty Acid Oxidation
Secretion
Transport
Reverse Transcription
Lipid Homeostasis
Cell Proliferation
Fatty Acid Beta-oxidation
Lipid Oxidation
Pathogenesis
Glycolysis
Tricarboxylic Acid Cycle
Aging
Gluconeogenesis

Spermatogenesis
Embryo Development
Inflammatory Response
Glucose Homeostasis
Translation
Cell Cycle
Cell Differentiation

PTMs

Oxidation

Phosphorylation

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACOX1

References

PMID: 8159712 by Varanasi U., et al. Isolation of the human peroxisomal acyl-CoA oxidase gene: organization, promoter analysis, and chromosomal localization.

PMID: 7876265 by Chu R., et al. Overexpression and characterization of the human peroxisomal acyl-CoA oxidase in insect cells.