ACD Antibodies

AND ACD ELISA kits, ACD Proteins

Many biological assays use antibodies to detect ACD, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ACD in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ACD antibodies...

We validate the specificity of these antibodies to ACD by testing them on tissues known to express ACD positively and negatively. Browse below to find the ACD antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ACD Infographic by Boster Bio

All ACD Products

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Product

Figures

Specificity

Applications

Price

PTOP (ACD) (NM_001082486) Human Recombinant Protein

$1062
Cat # PROTQ96AP0
20 µg

Anti-PTOP (ACD) Mouse Monoclonal Antibody [Clone ID: OTI2B1]

Human

IHC, WB

$523
Cat # M00985-1
100 µl

Anti-PTOP (ACD) Mouse Monoclonal Antibody [Clone ID: OTI1A2]

Human

Flow Cytometry, IF, WB

$523
Cat # M00985
100 µl

PTOP (ACD) (NM_001082486) Human Over-expression Lysate

Human

$628
Cat # LS065057
100 µg

ACD Overview

Facts about Adrenocortical dysplasia protein homolog.

ACD 3D structure. Source: alphafold

Adrenocortical dysplasia protein homolog (ACD)

Part of the shelterin complex (telosome) which is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends.

With no protective action, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 into single-stranded telomeric DNA.

Gene Information

Human
Gene Name:	ACD
Uniprot:	Q96AP0
Entrez:	65057

Family

Belongs to:

No superfamily

Alternative Names

adrenocortical dysplasia homolog (mouse); Pip1; PIP1Tint1; POT1 and TIN2 organizing protein; POT1 and TIN2-interacting protein; Ptop; PTOPTpp1; TIN2 interacting protein 1; TINT1adrenocortical dysplasia protein homolog; TPP1

Molecular Weight

Mass (kDA):
48.967 kDA

Genomic Context


Human

Location:	16q22.1
Sequence:	16; NC_000016.10 (67657512..67660832, complement)

Subcellular Localizations

Nucleus. Chromosome, telomere.

Diseases

Dermatitis
Contact Dermatitis
Dermatitis, Allergic Contact
Corneal Diseases
Anemia
Cataract
Intraocular Lymphoma
Angle Closure Glaucoma
Glaucoma
Intraocular Pressure Disorder
Anemia Of Chronic Disease
Inflammation
Malignant Neoplasms

Claudication (finding)
Myopia
Neoplasms
Intermittent Claudication
Iron Deficiency Anemia
Iron Deficiency
Refractive Errors

Interacting Proteins

DBNL
DPYSL3
EIF3G
ENSA
IPO5

IVL
LRRC25
PDLIM2
POT1
Pot1

RBKS
RGS3
Rnf8
SBDS
STIP1

STN1
STUB1
TBC1D10A
TBCD
TINF2

TUBB2A
UPF1
YWHAE

Pathways

Pathogenesis
Sensitization
Cell Death
Hypersensitivity
Transport
Secretion
Cell Division
Platelet Aggregation
Asymmetric Cell Division
Coagulation
Localization
Inflammatory Response
Cell Proliferation

Aging
Autophagic Cell Death
Autophagy
Translation
Immune Response
Cell Cycle
Hemostasis

PTMs

Oxidation
Phosphorylation
Cleavage
Reduction
Glycosylation
Methylation

Nitration
Carbamylation
Hydroxylation
Decarboxylation
Bromination
Acylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACD

References

PMID: 15181449 by Liu D., et al. PTOP interacts with POT1 and regulates its localization to telomeres.

PMID: 15537664 by Keegan C.E., et al. Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator.