BRCA1-A complex subunit Abraxas 1 (Abraxas1)

Involved in DNA damage response and double-strand break (DSB) repair. Part of the BRCA1-A complicated, acting as a central scaffold protein that assembles the various elements of the complex and mediates the recruitment of BRCA1.

The BRCA1-A complex specifically recognizes'Lys-63'-connected ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes'Lys-63'-linked ubiquitin on histones H2A and H2AX.