ABCC3 Antibodies

AND ABCC3 ELISA kits, ABCC3 Proteins

Many biological assays use antibodies to detect ABCC3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ABCC3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ABCC3 antibodies...

We validate the specificity of these antibodies to ABCC3 by testing them on tissues known to express ABCC3 positively and negatively. Browse below to find the ABCC3 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ABCC3 Infographic by Boster Bio

All ABCC3 Products

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Product

Figures

Specificity

Applications

Price

Anti-MRP3 (L1010) ABCC3 Antibody

Human, Mouse, Rat

$405
Cat # A02429
100ul

Anti-MRP3/ABCC3 Antibody Picoband®

Human

ELISA, IHC, WB

$370
Cat # A02429-1
100 μg/vial

MRP3 (ABCC3) (NM_003786) Human Over-expression Lysate

Human

$960
Cat # LS008714
100 µg

Anti-ABCC3 Antibody Picoband®

Human

ELISA, Flow Cytometry, WB

$370
Cat # A02429-2
100 µg/vial

ABCC3 Overview

Facts about Canalicular multispecific organic anion transporter 2.

ABCC3 3D structure. Source: alphafold

Canalicular multispecific organic anion transporter 2 (ABCC3)

May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).

. .

Gene Information

Human
Gene Name:	ABCC3
Uniprot:	O15438
Entrez:	8714

Family

Belongs to:

ABC transporter superfamily

Alternative Names

ABC31; ATP-binding cassette sub-family C member 3; ATP-binding cassette, sub-family C (CFTR/MRP), member 3; canalicular multispecific organic anion transporter 2; canicular multispecific organic anion transporter; cMOAT2; EC 3.6.3; EC 3.6.3.44; EC 6.3.2.4; MLP2DKFZp686E22157; MRP3MOAT-DEST90757; multidrug resistance associated protein; Multidrug resistance-associated protein 3; Multi-specific organic anion transporter D

Molecular Weight

Mass (kDA):
169.343 kDA

Genomic Context


Human

Location:	17q21.33
Sequence:	17; NC_000017.11 (50634881..50692253)

Tissue Specificity

Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney.

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Breast
Carcinoma
Cholestasis
Mammary Neoplasms
Liver Carcinoma
Adenocarcinoma
Malignant Paraganglionic Neoplasm
Liver Diseases
Malignant Neoplasm Of Lung
Liver Neoplasms
Lung Neoplasms

Hypertrophy
Injury To Liver
Hepatotoxicity
Inflammation
Melanoma
Hyperbilirubinemia
Neoplasm Metastasis

Pathways

Transport
Excretion
Localization
Drug Resistance
Drug Transport
Secretion
Intestinal Absorption
Cell Differentiation
Conjugation
Cellular Localization
Gene Silencing
Immune Response
Organic Anion Transport

Transepithelial Transport
Cell Proliferation
Transmembrane Transport
Anion Transport
Blood Circulation
Pathogenesis
Rna Interference

PTMs

Phosphorylation
Carboxylation
Reduction

Hydroxylation
Glycosylation
Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ABCC3

References

PMID: 9813153 by Uchiumi T., et al. Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport.

PMID: 9738950 by Kiuchi Y., et al. cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3).