ABCA1 Antibodies

AND ABCA1 ELISA kits, ABCA1 Proteins

Many biological assays use antibodies to detect ABCA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ABCA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ABCA1 antibodies...

We validate the specificity of these antibodies to ABCA1 by testing them on tissues known to express ABCA1 positively and negatively. Browse below to find the ABCA1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ABCA1 Infographic by Boster Bio

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ABCA1 Overview

Facts about Phospholipid-transporting ATPase ABCA1.

ABCA1 3D structure. Source: alphafold

Phospholipid-transporting ATPase ABCA1 (ABCA1)

cAMP-dependent and sulfonylurea-sensitive anion transporter. Involved in the efflux of intracellular cholesterol and phospholipids and their move to apoliproteins to form nascent high density lipoproteins/HDLs.

Gene Information

Human
Gene Name:	ABCA1
Uniprot:	O95477
Entrez:	19

Family

Belongs to:

ABC transporter superfamily

Alternative Names

ABC1; ABC-1; ABC1ATP-binding cassette transporter A1; ABCA1; ATP-binding cassette 1; ATP-binding cassette transporter 1; ATP-binding cassette, sub-family A (ABC1), member 1; CERP; Cholesterol efflux regulatory protein; EC 2.7.7.8; EC 2.8.1.8; EC 3.6.3; EC 3.6.3.41; FLJ14958; HDLDT1; membrane-bound; MGC164864; MGC165011; TGD; TGDATP-binding cassette sub-family A member 1

Molecular Weight

Mass (kDA):
254.302 kDA

Genomic Context


Human

Location:	9q31.1
Sequence:	9; NC_000009.12 (104781006..104928232, complement)

Tissue Specificity

Widely expressed, but most abundant in macrophages.

Subcellular Localizations

Membrane; Multi-pass membrane protein. Cell membrane. Endosome.

Diseases

Atherosclerosis
Tangier Disease
Cardiovascular Diseases
Inflammation
Diabetes Mellitus
Alzheimer's Disease
Coronary Artery Disease
Diabetes Mellitus, Non-insulin-dependent
Arteriosclerosis
Coronary Heart Disease
Hypercholesterolemia
Dyslipidemias

Heart Diseases
Dental Plaque
Liver Carcinoma
Obesity
Insulin Resistance
Malignant Neoplasms
Hyperlipidemia

Interacting Proteins

ABCA12
APOA1
CANX
CDC42
NR1H2

SNTA1
SNTB1
STX12

Pathways

Cholesterol Efflux
Transport
Cholesterol Transport
Reverse Cholesterol Transport
Cholesterol Homeostasis
Secretion
Pathogenesis
Phospholipid Efflux
Lipid Homeostasis
Excretion
Lipid Transport
Localization
Intestinal Cholesterol Absorption

Insulin Secretion
Cell Proliferation
Cholesterol Esterification
Phagocytosis
Endocytosis
Inflammatory Response
Rna Interference

PTMs

Phosphorylation
Oxidation
Acetylation
Cleavage
Biotinylation
Methylation
Reduction
Hydroxylation
Dephosphorylation
Ubiquitination

Acylation
Glycosylation
Geranylgeranylation
Demethylation
Carboxylation
Phosphorothioation
Ribosylation
Nitration
Deacetylation
Palmitoylation

Research Areas

ABC Transporters
Astrocyte Markers
Cancer
Cellular Markers
Cholesterol Metabolism

Diabetes Research
Glia Markers
Golgi Apparatus Markers
Lipid and Metabolism
Neuroscience

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ABCA1

References

PMID: 10884428 by Santamarina-Fojo S., et al. Complete genomic sequence of the human ABCA1 gene: analysis of the human and mouse ATP-binding cassette A promoter.

PMID: 11352567 by Qiu Y., et al. Human and mouse ABCA1 comparative sequencing and transgenesis studies revealing novel regulatory sequences.