Research Spotlight - September 2022

The September issue of Research Spotlight has arrived! We’re happy to present 10 recent publications from scientists whom Boster has served.

In this month’s featured publications, scientists highlighted the role of mTORC1 in hyperactive tumors for precision immunotherapy, and investigated the regulatory mechanisms of NF-κB and AMPK/mTOR signaling as therapeutic targets for osteoarthritis and cardiovascular disease, respectively.

Researchers also explored how resveratrol promotes recovery from spinal cord injury by improving intestinal microbiota. Furthermore, scientists proposed a magnetic soft robotic bladder to help underactive bladders.

Several nanotherapeutics are introduced, such as TME-responsive MnO2-melittin nanoparticles for enhancing cancer vaccine efficiency, bioactive antibacterial hydromembrane for accelerating diabetic wound healing, and MSC-derived extracellular vesicles for treating brain injury.

Scroll down to learn more about these discoveries!

Midkine Expression by Stem-Like Tumor Cells Drives Persistence to mTOR Inhibition and an Immune-Suppressive Microenvironment

Authors: Tang, Y., Kwiatkowski, D.J., Henske, E.P.
Journal: Nature Communications

mTORC1 is hyperactive in multiple cancer types1,2. Here, we performed integrative analysis of single cell transcriptomic profiling, paired T cell receptor (TCR) sequencing, and spatial transcriptomic profiling on Tuberous Sclerosis Complex (TSC) associated tumors with mTORC1 hyperactivity, and identified a stem-like tumor cell state...

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Cited Boster Product(s): Anti-Cathepsin K/CTSK Antibody Picoband™ (PB9856); Human Midkine ELISA Kit PicoKine® (EK1235)

Magnetic Soft Robotic Bladder for Assisted Urination

Authors: Yang, Y., Wang, J., Wang, L., Wu, Q., Ling, L., Yang, Y., Ning, S…
Journal: Science Advances

The poor contractility of the detrusor muscle in underactive bladders (UABs) fails to increase the pressure inside the UAB, leading to strenuous and incomplete urination. However, existing therapeutic strategies by modulating/ repairing detrusor muscles, e.g., neurostimulation and regenerative medicine, still have low efficacy...

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Cited Boster Product(s): Cell Counting Kit-8 (CCK-8) (AR1160)

MnO2-Melittin Nanoparticles Serve as an Effective Anti-Tumor Immunotherapy by Enhancing Systemic Immune Response

Authors: Tang, S., Zhou, L., He, H., Cui, L., Ren, Z., Tai, Y., Xie, Z., Cao, Y…
Journal: Biomaterials

Cancer vaccines are viewed as a promising immunotherapy to eradicate malignant tumors and aim to elicit the patients’ own tumor-specific immune response against tumor cells. However, few cancer vaccines have been applied due to the low immunogenicity of antigen and invalidation of adjuvant. Herein, we designed a tumor microenvironment...

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Cited Boster Product(s): Mouse IFN Gamma / IFNG / Interferon Gamma ELISA Kit PicoKine® (EK0375); Mouse IL-6/Interleukin-6 ELISA Kit PicoKine® (EK0411); Mouse TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine® (EK0527); Mouse CXCL10/IP-10 ELISA Kit PicoKine® (EK0736)

Antibacterial Coaxial Hydro-Membranes Accelerate Diabetic Wound Healing by Tuning Surface Immunomodulatory Functions

Authors: Zhang, W., Xia, S., Weng, T., Yang, M., Shao, J., Zhang, M., Wang, J…
Journal: Materials Today Bio

Diabetic foot ulcers, typical non-healing wounds, represent a severe clinical problem. Advanced glycation end-products (AGEs), which create a prolonged pro-inflammatory micro-environment in defective sites, can be responsible for refractoriness of these ulcers. Macrophages are polarized to the M2 phenotype to facilitate the transition...

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Cited Boster Product(s): DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) For Nucleic Acid Staining (AR1176)

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Afford Neuroprotection by Modulating PI3K/AKT Pathway and Calcium Oscillations

Authors: Turovsky, E.A., Golovicheva, V.V., Varlamova, E.G., Danilina, T.I…
Journal: International Journal of Biological Sciences

Mesenchymal stromal cells (MSC) are widely recognized as potential effectors in neuroprotective therapy. The protective properties of MSC were considered to be associated with the secretion of extracellular vesicles (MSC-EV). We explored the effects of MSC-EV in vivo on models of traumatic and hypoxia-ischemia (HI) brain injury...

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Cited Boster Product(s): Anti-TSG101 Rabbit Monoclonal Antibody (M01233)

Role of RNA m6A Modification in Titanium Dioxide Nanoparticle-Induced Acute Pulmonary Injury: An in vitro and in vivo Study

Authors: Ruan, F., Liu, C., Wang, Y., Cao, X., Tang, Z., Xu, J., Zeng, J., Yin, H…
Journal: Environmental Pollution

RNA N6-methyladenosine (m6A) modification regulates the cell stress response and homeostasis, but whether titanium dioxide nanoparticle (nTiO2)-induced acute pulmonary injury is associated with the m6A epitranscriptome and the underlying mechanisms remain unclear. Here, the potential association between m6A modification and the bioeffects...

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Cited Boster Product(s): Anti-ALKBH5 Antibody Picoband™ (A03360)

Resveratrol Suppresses Microglial Activation and Promotes Functional Recovery of Traumatic Spinal Cord via Improving Intestinal Microbiota

Authors: He, N., Shen, G., Jin, X., Li, H., Wang, J., Xu, L., Chen, J., Cao, X…
Journal: Pharmacological Research

Spinal cord injury (SCI) can change the intestinal microbiota pattern and corresponding metabolites, which in turn affect the prognosis of SCI. Among many metabolites, short-chain fatty acids (SCFAs) are critical for neurological recovery after SCI. Recent research has shown that resveratrol exerts anti-inflammatory properties...

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Cited Boster Product(s): Anti-GFAP Antibody Picoband™ (Monoclonal, 3F2) (M00213-8)

Radiation Combined With KRAS-MEK Inhibitors Enhances Anticancer Immunity in KRAS-Mutated Tumor Models

Authors: Zheng, Y., Liu, Y., Zhang, F., Su, C., Chen, X., Zhang, M., Sun, M…
Journal: Translational Research

KRAS mutation is a common driver in solid tumors, and KRAS-mutated tumors are relatively resistant to radiotherapy. Therefore, we investigated the combined effect of radiation and KRAS-MEK inhibitors (AMG510 and trametinib) in KRAS-mutated tumors. The expression of programmed death-ligand 1 (PD-L1), major histocompatibility complex...

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Cited Boster Product(s): Mouse CXCL10/IP-10 ELISA Kit PicoKine® (EK0736)

Circular RNA circNFKB1 Promotes Osteoarthritis Progression Through Interacting with ENO1 and Sustaining NF-κB Signaling

Authors: Tang, S., Nie, X., Ruan, J., Cao, Y., Kang, J., Ding, C.
Journal: Cell Death & Disease

Inflammatory cytokines-induced activation of the nuclear factor κB (NF-κB) pathway plays a critical role in the pathogenesis of osteoarthritis (OA). Circular RNA (circRNA) has been identified as important epigenetic factor in numerous diseases. However, the biological roles of inflammation-related circRNAs in regulating OA pathogenesis...

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Cited Boster Product(s): HRP Conjugated AffiniPure Goat Anti-Rabbit IgG (H+L) (BA1054); HRP Conjugated AffiniPure Goat Anti-Mouse IgG (H+L) (BA1050)

Silencing TUFM Inhibits Development of Monocrotaline-Induced Pulmonary Hypertension by Regulating Mitochondrial Autophagy via AMPK/mTOR Signal Pathway

Authors: Wei, R., Lv, X., Fang, C., Liu, C., Ma, Z., Liu, K.
Journal: Oxidative Medicine and Cellular Longevity

Pulmonary arterial hypertension (PAH) is an extremely malignant cardiovascular disease which mainly involves the uncontrollable proliferation of the pulmonary arterial smooth muscular cells (PASMCs). Recent studies have confirmed that mitochondria play an important role in the pathogenesis of pulmonary hypertension through sensing...

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Cited Boster Product(s): Anti-ULK1 Antibody Picoband™ (A00584-1)