Research Spotlight - September 2021

The September edition of Research Spotlight presents 10 recent publications from scientists whom Boster has served.

This month’s selected research papers characterize the underlying mechanisms of several cancers, HIV, and other systemic diseases. Among the studies, monoclonal antibodies and a tumor nanovaccine are explored as therapeutic treatments for different cancers.

Scientists also demonstrate how a 3D-printed biphasic scaffold can enhance cartilage regeneration. In addition, the role of PEDF in collagen synthesis and its implications for tissue expansion in plastic surgery is investigated.

Keep scrolling to find out more about these research studies.

Characterizing Dedifferentiation of Thyroid Cancer by Integrated Analysis

Authors: Luo, H., Xia, X., Kim, G.D., Liu, Y., Xue, Z., Zhang, L., Shu, Y., Yang, T...
Journal: Science Advances

Understanding of dedifferentiation, an indicator of poo prognosis for patients with thyroid cancer, has been hampered by imprecise and incomplete characterization of its heterogeneity and its attributes. Using single-cell RNA sequencing, we explored the landscape of thyroid cancer at single-cell resolution with 46,205 cells and...

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Cited Boster Product(s): Anti-Vimentin Antibody Picoband™ (PB9359); Anti-E Cadherin 1/CDH1 Antibody Picoband™ (PB9561)

Oral Immune Dysfunction is Associated with the Expansion of FOXP3+PD-1+Amphiregulin+ T Cells During HIV Infection

Authors: Bhaskaran, N., Schneider, E., Faddoul, F., da Silva, A.P., Asaad, R...
Journal: Nature Communications

>Residual systemic inflammation and mucosal immune dysfunction persist in people living with HIV, despite treatment with combined anti-retroviral therapy, but the underlying immune mechanisms are poorly understood. Here we report that the altered immune landscape of the oral mucosa of HIV-positive patients on therapy involves...

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Cited Boster Product(s): Human CD14 ELISA Kit PicoKine™ (EK0694); Human TLR2/Toll-Like Receptor 2 ELISA Kit PicoKine™ (EK0906); Human Cotinine ELISA Kit (Competitive EIA) (EK7035); Human Amphiregulin(AR) / AREG ELISA Kit PicoKine™ (EK0304); Human IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine™ (EK0392); Human IL-6/Interleukin-6 ELISA Kit PicoKine™ (EK0410)

Increased Plasmin-Mediated Proteolysis of L1CAM in a Mouse Model of idiopathic Normal Pressure Hydrocephalus

Authors: Yang, D., Yang, H., Luiselli, G., Ogagan, C., Dai, H., Chiu, L...
Journal: PNAS (Proceedings of the National Academy of Sciences of the United States of America)

Idiopathic normal pressure hydrocephalus (iNPH) is a common neurological disorder that is characterized by enlarged cerebral ventricles, gait difficulty, incontinence, and dementia. iNPH usually develops after the sixth decade of life in previously asymptomatic individuals. We recently reported that loss-of-function deletions in CWH43...

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Cited Boster Product(s): Anti-Plasminogen Antibody Picoband™ (A03674-1)

Cooperating Minimalist Nanovaccine with PD-1 Blockade for Effective and Feasible Cancer Immunotherapy

Authors: Jiang, M., Zhao, L., Cui, X., Wu, X., Zhang, Y., Guan, X., Ma, J...
Journal: Journal of Advanced Research

Introduction: Tumor vaccine has been a research boom for cancer immunotherapy, while its therapeutic outcome is severely depressed by the vulnerable in vivo delivery efficiency. Moreover, tumor immune escape is also another intractable issue, which has badly whittled down the therapeutic efficiency. Objectives: Our study aims to solve...

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Cited Boster Product(s): FITC Conjugated Avidin (BA1125)

Blockade of CHRNB2 Signaling with a Therapeutic Monoclonal Antibody Attenuates the Aggressiveness of Gastric Cancer Cells

Authors: Kanda, M., Shimizu, D., Nakamura, S., Sawaki, K., Umeda, S...
Journal: Oncogene

Here, we evaluated the therapeutic potential of antibodies (Abs) targeting cholinergic receptor nicotinic beta 2 subunit (CHRNB2) in gastric cancer. To investigate the effects of these Abs on malignant phenotypes in vitro and in mouse xenograft models, we generated gene knockouts through genome editing, performed RNA interference...

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Cited Boster Product(s): Anti-CHRNB2 Antibody (A02761)

LRRC4 Mediates the Formation of Circular RNA CD44 to Inhibit GBM Cell Proliferation

Authors: Feng, J., Ren, X., Fu, H., Li, D., Chen, X., Zu, X., Liu, Q., Wu, M.
Journal: Molecular Therapy: Nucleic Acids

Mounting evidence revealed that dysregulation of circRNAs involved in the development of glioblastoma. LRRC4 has already been proved as a tumor suppressor in glioblastoma. However, whether LRRC4 can regulate the formation of circular RNA is still not yet understood. In this study, LRRC4 is found to interact with SAM68. LRRC4 promotes...

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Cited Boster Product(s): Anti-Ki67/MKI67 Antibody Picoband™ (PB9026)

3D Printed PCL/GelMA Biphasic Scaffold Boosts Cartilage Regeneration Using Co-Culture of Mesenchymal Stem Cells and Chondrocytes: In vivo Study

Authors: Cao, Y., Cheng, P., Sang, S., Xiang, C., An, Y., Wei, X., Yan, Y., Li, P.
Journal: Materials & Design

Cartilage injury is difficult to self-repair, which poses a challenge to scaffold design and selection of seeded cells for cartilage tissue engineering. In this study, we presented a biphasic scaffold consisting of a cells-encapsulated biodegradable gelatin methacrylate (GelMA) hydrogel on the upper layer and a microporous...

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Cited Boster Product(s): DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) For Nucleic Acid Staining (AR1176); Goat Anti-Rabbit IgG (H+L) Secondary Antibody, FITC Conjugated (BA1105)

Circulating Mir-140 and Leptin Improve the Accuracy of the Differential Diagnosis Between Psoriatic Arthritis and Rheumatoid Arthritis: a Case-Control Study

Authors: Cheleschi, S., Tenti, S., Bedogni, G., Fioravanti, A.
Journal: Translational Research

The differential diagnosis of psoriatic arthritis (PsA) and rheumatoid arthritis (RA) is difficult because of the lack of diagnostic clinical signs and reliable biomarkers. This study investigated microRNAs (miRNA) and adipokines as potential additional markers to discriminate PsA from RA. The expression profile of miRNA...

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Cited Boster Product(s): Human Chemerin/RARRES2 ELISA Kit PicoKine™ (EK1329); Human Leptin ELISA Kit PicoKine™ (EK0437); Human IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine™ (EK0392); Human IL-6/Interleukin-6 ELISA Kit PicoKine™ (EK0410); Human TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine™ (EK0525)

Secreted PEDF Modulates Fibroblast Collagen Synthesis Through M1 Macrophage Polarization Under Expanded Condition

Authors: Zhang, Y., Yu, Z., Lei, L., Song, Y., Liu, S., Cui, J., Dong, C., Ding, J...
Journal: Biomedicine & Pharmacotherapy

Tissue expansion is widely used to obtain new skin tissue for repairing defects in the clinical practice of plastic surgery. One major complication can be dermal thinning during expansion, which usually leads to skin rupture. Collagen synthesis can determine dermal thickness and can be influenced by macrophage polarization during...

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Cited Boster Product(s): Human PEDF/SerpinF1 ELISA Kit PicoKine™ (EK0896); Anti-PEDF SERPINF1 Antibody (A02034)

Effect of Long-Term Exposure to Acrylamide on Endoplasmic Reticulum Stress and Autophagy in Rat Cerebellum

Authors: Wang, Y., Duan, L., Zhang, X., Jiao, Y., Liu, Y., Dai, L., Yan, H.
Journal: Ecotoxicology and Environmental Safety

Acrylamide (ACR) is a widely used chemical compound that has neurotoxicity in human, but whether ACR could impair the cerebellum and the related mechanism were still unknown. This study aimed to observe the changes in behavioral performance and cerebellar morphology caused by chronic ACR exposure, and to evaluate its influence on...

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Cited Boster Product(s): Broad Spectrum Phosphatase Inhibitor Cocktail (AR1183); BCA Protein Assay Kit (AR0146)