Research Spotlight – September 2020

In our September edition of Research Spotlight, we feature 10 recently published research papers from scientists whom Boster has served.

This month’s selected research publications examine the mechanisms of plaque rupture, ELABELA in DOCA/salt-induced hypertension, BMSC-derived exosomes in peripheral nerve regeneration, TMZ in diabetic nephropathy, and MCL on LPS-induced inflammation.

Among the studies, scientists also investigate nanomicelle’s effect on paclitaxel’s immune-activation ability. In addition, the connection of cancer-associated SNPs in lncRNA for lung cancer and the role of IL-6 for colorectal cancer are explored.

Scroll down to learn more about these new scientific discoveries.

Nanomicelle protects the immune activation effects of Paclitaxel and sensitizes tumors to anti-PD-1 Immunotherapy

Authors: Yang, Q., Shi, G., Chen, X., Lin, Y., Cheng, L., Jiang, Q., Yan, X., Jiang, M...
Journal: Theranostics

Paclitaxel (PTX) has shown pleiotropic immunologic effects on the tumor microenvironment, and nanomicelle has emerged as a promising strategy for PTX delivery. However, the detailed mechanisms remain to be fully elucidated. Meanwhile, immunogenic cell death (ICD) is an effective approach to activate the immune system. This study...

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Cited Boster Product(s): Mouse CXCL9/Mig ELISA Kit PicoKine™ (EK0733)

Parallel Murine and Human Plaque Proteomics Reveals Pathways of Plaque Rupture

Authors: Vaisar, T., Hu, J.H., Airhart, N., Fox, K., Heinecke, J., Nicosia, R.F...
Journal: Circulation Research

Plaque rupture is the proximate cause of most myocardial infarctions and many strokes. However, the molecular mechanisms that precipitate plaque rupture are unknown. By applying proteomic and bioinformatic approaches in mouse models of protease-induced plaque rupture and in ruptured human plaques, we aimed to illuminate...

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Cited Boster Product(s): Anti-Heparan Sulfate Proteoglycan 2/HSPG2 Antibody Picoband™ (PB9277)

Burkholderia pseudomallei interferes with host lipid metabolism via NR1D2-mediated PNPLA2/ATGL suppression to block autophagy-dependent inhibition of infection

Authors: Tang, M., Hu, Z., Rao, C., Chen, J., Yuan, S., Zhang, J., Mao, C., Yan, J...
Journal: Autophagy

Burkholderia pseudomallei which causes melioidosis with high mortality in humans, has become a global public health concern. Recently, infection-driven lipid droplet accumulation has been related to the progression of host-pathogen interactions, and its contribution to the pathogenesis of infectious disease has been investigated. Here, we demonstrated that...

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Cited Boster Product(s): Tris Buffered Saline (TBS) Powder (AR0031)

A SNP-mediated lncRNA (LOC146880) and microRNA (miR-539-5p) interaction and its potential impact on the NSCLC risk

Authors: Feng, T., Feng, N., Zhu, T., Li, Q., Zhang, Q., Wang, Y., Gao, M., Zhou, B…
Journal: Journal of Experimental & Clinical Cancer Research

Many cancer-associated single nucleotide polymorphisms (SNPs) are located in the genomic regions of long non-coding RNAs (lncRNAs). Mechanisms of these SNPs in connection to cancer risk are not fully understood. Association of SNP (rs140618127) in lncRNA LOC146880 with non-small cell lung cancer (NSCLC) was evaluated...

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Cited Boster Product(s): 4% Paraformaldehyde (PFA) Solution In PBS (AR1068)

ELABELA attenuates deoxycorticosterone acetate/salt-induced hypertension and renal injury by inhibition of NADPH oxidase/ROS/NLRP3 inflammasome pathway

Authors: Chen, Z., Wu, C., Liu, Y., Li, H., Zhu, Y., Huang, C., Lin, H., Qiao, Q...
Journal: Cell Death & Disease

ELABELA (ELA), a 32-residue hormone peptide abundantly expressed in adult kidneys, has been identified as a novel endogenous ligand for APJ/Apelin receptor. The aim of this study was to investigate the role of ELA in deoxycorticosterone acetate (DOCA)/salt-induced hypertension and further explore the underlying mechanism. In DOCA/salt-treated...

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Cited Boster Product(s): HRP Conjugated Streptavidin (BA1088)

Dose-effect relationship and molecular mechanism by which BMSC-derived exosomes promote peripheral nerve regeneration after crush injury

Authors: Zhao, J., Ding, Y., He, R., Huang, K., Liu, L., Jiang, C., Liu, Z., Wang, Y…
Journal: Stem Cell Research & Therapy

The development of new treatment strategies to improve peripheral nerve repair after injury, especially those that accelerate axonal nerve regeneration, is very important. The aim of this study is to elucidate the molecular mechanisms of how bone marrow stromal cell (BMSC)-derived exosomes (EXOs) participate in peripheral nerve regeneration...

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Cited Boster Product(s): DAPI For Nucleic Acid Staining (AR1176)

Bergenin as a Novel Urate-Lowering Therapeutic Strategy for Hyperuricemia

Authors: Chen, M., Ye, C., Zhu, J., Zhang, P., Jiang, Y., Lu, X., & Wu, H.
Journal: Frontiers in Cell and Developmental Biology

Bergenin is a C-glucoside of 4-O-methyl gallic acid isolated from several medicinal plants and has multiple biological activities. The aim of this study was to assess the potential usefulness of bergenin in hyperuricemia. We found that bergenin reduced serum urate levels in hyperuricemia mice by promoting renal and gut uric acid excretion...

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Cited Boster Product(s): Mouse IL-1RA/IL1RN ELISA Kit PicoKine™ (EK0783)

Interleukin-6 Promotes Epithelial-Mesenchymal Transition and Cell Invasion through Integrin β6 Upregulation in Colorectal Cancer

Authors: Sun, Q., Shang, Y., Sun, F., Dong, X., Niu, J., & Li, F.
Journal: Oxidative Medicine and Cellular Longevity

The metastatic potential of colorectal cancer (CRC) is intensively promoted by the tumor microenvironment (TME) in a paracrine manner. As a pleiotropic inflammatory cytokine, Interleukin-6 (IL-6) is produced and involved in CRC, the same scenario where integrin αvβ6 also becomes upregulated. However, the relationship between IL-6 and integrin αvβ6 as...

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Cited Boster Product(s): Human IL-6 ELISA Kit PicoKine™ (EK0410)

Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1

Authors: Yang, Y., Wang, Y., He, Z., Liu, Y., Chen, C., Wang, Y., Wang, D.W...
Journal: Frontiers in Pharmacology

Trimetazidine (TMZ), as a metabolic regulator, is effective in treatment of coronary atherosclerotic heart disease with rare side effects in the clinic for long years. Interestingly, studies have shown that TMZ protects against several acute kidney injuries (AKI). However, the effect of TMZ on chronic kidney diseases (CKD) remains unknown. This study...

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Cited Boster Product(s): BCA Protein Assay Kit (AR0146)

Micheliolide Attenuates Lipopolysaccharide-Induced Inflammation by Modulating the mROS/NF-κB/NLRP3 Axis in Renal Tubular Epithelial Cells

Authors: Lei, X., Li, S., Luo, C., Wang, Y., Liu, Y., Xu, Z., Huang, Q., Zou, F...
Journal: Mediators of Inflammation

Chronic kidney disease is a common disease closely related to renal tubular inflammation and oxidative stress, and no effective treatment is available. Activation of the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is an important factor in renal inflammation, but the mechanism remains unclear...

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Cited Boster Product(s): Rat IL-18 ELISA Kit PicoKine™ (EK0592)