Research Spotlight - October 2021

We're delighted to bring you our October edition of Research Spotlight, featuring 10 new publications of various fields from scientists whom Boster has served.

This month, research papers delve into nanotechnology advancements using polydopamine nanoparticles, PLGA nanoparticles, and HA-coated collagen nanofibers for cancer treatments and regenerative medicine.

Scientists also investigate how exercise can ameliorate tumor-associated anemia, how the SARS-CoV-2 virus crosses the blood-brain barrier, and how parvalbumin-positive interneurons (PVIs) affect depression. In addition, researchers generate an automated human iPSC neuron culturing platform for better Alzheimer’s disease modeling.

Scroll down to check out these new discoveries and more from fellow scientists!

Remodeling of Metabolism and Inflammation by Exercise Ameliorates Tumor-Associated Anemia

Authors: Furrer, R., Jauch, A.J., Rao, T.N., Dilbaz, S., Rhein, P., Steurer, S.A….
Journal: Science Advances

A considerable number of patients with cancer suffer from anemia, which has detrimental effects on quality of life and survival. The mechanisms underlying tumor-associated anemia are multifactorial and poorly understood. Therefore, we aimed at systematically assessing the patho-etiology of tumor-associated anemia in mice...

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Cited Boster Product(s): Mouse EPO/Erythropoietin ELISA Kit PicoKine™ (EK0333)

Biomimetic Nanoparticles Carrying a Repolarization Agent of Tumor-Associated Macrophages for Remodeling of the Inflammatory Microenvironment Following Photothermal Therapy

Authors: Yue, Y., Li, F., Li, Y., Wang, Y., Guo, X., Cheng, Z., Li, N., Ma, X....
Journal: ACS Nano

The complete regression of residual tumors after photothermal therapy (PTT) depends on the activation and recognition of the immune system. However, the inevitable local inflammation after PTT in residual tumor recruits abundant abnormal immune cells, especially the tumor-associated macrophages (TAMs) which further promote immune...

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Cited Boster Product(s): Anti-GAPDH Antibody Picoband™ (A00227-1)

SARS-CoV-2 Crosses the Blood–Brain Barrier Accompanied with Basement Membrane Disruption Without Tight Junctions Alteration

Authors: Zhang, L., Zhou, L., Bao, L., Liu, J., Zhu, H., Lv, Q., Liu, R., Chen, W….
Journal: Signal Transduction and Targeted Therapy

SARS-CoV-2 has been reported to show a capacity for invading the brains of humans and model animals. However, it remains unclear whether and how SARS-CoV-2 crosses the blood–brain barrier (BBB). Herein, SARS-CoV-2 RNA was occasionally detected in the vascular wall and perivascular space, as well as in brain microvascular endothelial...

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Cited Boster Product(s): IHC Enzyme Antigen Retrieval Reagent (AR0022)

Intracellular Delivery of Anti-BCR/ABL Antibody by PLGA Nanoparticles Suppresses the Oncogenesis of Chronic Myeloid Leukemia Cells

Authors: Jiang, G., Huang, Z., Yuan, Y., Tao, K., Feng, W.
Journal: Journal of Hematology & Oncology

The pathogenesis of chronic myeloid leukemia (CML) is the formation of the BCR/ABL protein, which is encoded by the bcr/abl fusion gene, possessing abnormal tyrosine kinase activity. Despite the wide application of tyrosine kinase inhibitors (TKIs) in CML treatment, TKIs drug resistance or intolerance limits their further usage...

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Cited Boster Product(s): Cell Counting Kit-8 (CCK-8) (AR1160)

Improved Modeling of Human AD with an Automated Culturing Platform for iPSC Neurons, Astrocytes and Microglia

Authors: Bassil, R., Shields, K., Granger, K., Zein, I., Ng, S., Chih, B.
Journal: Nature Communications

Advancement in human induced pluripotent stem cell (iPSC) neuron and microglial differentiation protocols allow for disease modeling using physiologically relevant cells. However, iPSC differentiation and culturing protocols have posed challenges to maintaining consistency. Here, we generated an automated, consistent, and long-term...

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Cited Boster Product(s): Anti-EAAT1/SLC1A3 Antibody (PA2185)

CREBH Normalizes Dyslipidemia and Halts Atherosclerosis in Diabetes by Decreasing Circulating Remnant Lipoproteins

Authors: Shimizu-Albergine, M., Basu, D., Kanter, J.E., Kramer, F., Kothari, V...
Journal: Journal of Clinical Investigation

Loss-of-function mutations in the transcription factor CREB3L3 (CREBH) associate with severe hypertriglyceridemia in humans. CREBH is believed to lower plasma triglycerides by augmenting the action of lipoprotein lipase (LPL). However, by using a mouse model of type 1 diabetes mellitus (T1DM), we found that greater liver expression...

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Cited Boster Product(s): Mouse FGF21 ELISA Kit PicoKine™ (EK1379)

HA-Coated Collagen Nanofibers for Urethral Regeneration via in situ Polarization of M2 Macrophages

Authors: Niu, Y., Stadler, F.J., Yang, X., Deng, F., Liu, G., Xia, H.
Journal: Journal of Nanobiotechnology

In situ tissue engineering utilizes the regenerative potential of the human body to control cell function for tissue regeneration and has shown considerable prospect in urology. However, many problems are still to be understood, especially the interactions between scaffolds and host macrophages at the wound site and how these...

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Cited Boster Product(s): Mouse TNF Alpha/Tumor Necrosis Factor PicoKine™ Quick ELISA Kit (FEK0527) Mouse IL-10/Interleukin-10 ELISA Kit PicoKine™ (EK0417)

Colitis-Linked to Endoplasmic Reticulum Stress Induces Trypsin Activity Affecting Epithelial Functions

Authors: Tapias, N.S., Souza, A.D., Fourcade, C.R., Nicaise, M.Q., Blanpied, C…
Journal: Journal of Crohn's and Colitis

Background: Intestinal epithelial cells (IECs) from inflammatory bowel disease (IBD) patients exhibit excessive induction of Endoplasmic Reticulum stress (ER stress) linked to altered intestinal barrier function and inflammation. Colonic tissues and luminal content of IBD patients are also characterized by increased serine protease...

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Cited Boster Product(s): Human TFF3/ITF ELISA Kit PicoKine™ (EK1234)

LncRNA ZNFTR Functions as an Inhibitor in Pancreatic Cancer by Modulating ATF3/ZNF24/VEGFA Pathway

Authors: Li, W., Han, S., Hu, P., Chen, D., Zeng, Z., Hu, Y., Xu, F., Tang, J…
Journal: Cell Death & Disease

The majority of long non-coding RNAs (lncRNAs) have been discovered to be overexpressed in pancreatic cancer (PC) and served as promoters in the tumorigenesis of PC, while the inhibitory functions of lncRNAs in the development of PC have not been fully elucidated yet. LncRNA microarray was adopted to analyze the differential...

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Cited Boster Product(s): Human VEGF ELISA Kit PicoKine™ (EK0539)

Defects of Parvalbumin-Positive Interneurons in the Ventral Dentate Gyrus Region are Implicated Depression-Like Behavior in Mice

Authors: Chen, S., Chen, F., Amin, N., Ren, Q., Ye, S., Hu, Z., Tan, X…
Journal : Brain, Behavior, and Immunity

Depression is an increasingly common but extremely serve mood disorder that remains poorly understood and inadequately treated. Fast-spiking parvalbumin-positive interneurons (PVIs), a subpopulation of GABAergic interneurons (GABA, g-aminobutyric acid), exhibit a widespread distribution throughout the hippocampus, and has been...

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Cited Boster Product(s): Anti-Nitric Oxide Synthase (Inducible) Nos2 Antibody (A00368-1)