Research Spotlight - November 2018

At Boster, our customers’ research is our priority. Our mission is to help customers achieve their research goals so that they can stay on the cutting edge of research.

This November, we’d like to feature a selected number of recently published research from the scientists whom Boster has served. Scroll down to see 10 research discoveries from different fields.

Engineered nanoparticles disguised as macrophages for trapping lipopolysaccharide and preventing endotoxemia

Authors: Shen, S., Han, F., Yuan, A., Wu, L., Cao, J., Qian, J., Qi, X., Yan, Y...
Journal: Biomaterials

Endotoxemia is a severe pathophysiology induced by bacterial endotoxin (also known as lipopolysaccharide, LPS), causing high mortality in clinic due to the life-threatening syndromes, such as sepsis, shock, and multiple organ dysfunction...

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Cited Boster Product(s): Mouse TNF⍺ PicoKine™ ELISA Kit (EK0527); Mouse IL-6 PicoKine™ ELISA Kit (EK0411)

Preparation of self‐regulating/anti‐adhesive hydrogels and their ability to promote healing in burn wounds

Authors: Liang, M., Chen, Z., Wang, F., Liu, L., Wei, R., & Zhang, M.
Journal: Journal of Biomedical Materials Research Part B: Applied Biomaterials

Few burn dressings can self‐regulate the optimal humidity levels that are required for wound healing, while also providing good anti‐adhesive properties to prevent damage that can occur when wound dressings are changed...

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Cited Boster Product(s): Antibody Diluent (AR1016); HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002); DAB Chromogenic Substrate Kit (Brown) (AR1022)

CD90 determined two subpopulations of glioma-associated mesenchymal stem cells with different roles in tumour progression

Authors: Q., Yi, D.Y., Xue, B.Z., Wen, W.W., Lu, Y.P., Abdelmaksou, A...
Journal: Cell Death & Disease

Human glioma-associated mesenchymal stem cells (gbMSCs) are the stromal cell components that contribute to the tumourigenesis of malignant gliomas. Recent studies have shown that gbMSCs consist of two distinct subpopulations...

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Cited Boster Product(s): Hematoxylin Counterstain Solution (AR0005); Goat Anti-Rabbit IgG (H+L) Secondary Antibody

Histone-lysine N-methyltransferase SETD7 is a potential serum biomarker for colorectal cancer patients

Authors: Duan, B., Bai, J., Qiu, J., Wang, J., Tong, C., Wang, X., Miao, J...
Journal: EBioMedicine

Background: There is an urgent need for the identification of new, clinically useful biomarkers of CRC to enhance diagnostic and prognostic capabilities. Methods: We performed proteomic profiling on serum samples from paired...

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Cited Boster Product(s): MTT Cell Proliferation & Cytotoxicity Assay Kit (AR1156)

Hypoxia‐driven paracrine osteopontin/integrin αvβ3 signaling promotes pancreatic cancer cell epithelial‐mesenchymal transition and cancer stem cell‐like properties by modulating FOXM1

Authors: Cao, J., Li, J., Sun, L., Qin, T., Xiao, Y., Chen, K., Qian, W., Duan, W...
Journal: Molecular Oncology

Pancreatic stellate cells (PSCs), a key component of the tumor microenvironment, contribute to tumor invasion, metastasis, and chemoresistance. Osteopontin (OPN), a phosphorylated glycoprotein, is overexpressed in pancreatic...

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Cited Boster Product(s): Human OPN PicoKine™ ELISA Kit (EK0482)

FGFR2 Promotes Gastric Cancer Progression by Inhibiting the Expression of Thrombospondin4 via PI3K-Akt-Mtor Pathway

Authors: Huang, T., Liu, D., Wang, Y., Li, P., Sun, L., Xiong, H., Dai, Y...
Journal: Cellular Physiology and Biochemistry

Background/Aims: Fibroblast growth factor receptor 2 (FGFR2) has attracted considerable interest as a therapeutic target in gastric cancer (GC). There is growing evidence to suggest that the bioavailability of the potent pro-tumor function...

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Cited Boster Product(s): BCA Protein Assay Kit (AR0146); Cell Counting Kit-8 (CCK-8) (AR1160)

Liver X receptor activation reduces gastric cancer cell proliferation by suppressing Wnt signalling via LXRβ relocalization

Authors: Wang, Q., Feng, F., Wang, J., Ren, M., Shi, Z., Mao, X., Zhang, H...
Journal: Journal of Cellular and Molecular Medicine

Liver X receptors (LXRs) are involved in various diseases associated with lipid disorders, and in regulating cancer cell proliferation. However, the underlying molecular mechanisms, especially those in gastric cancer (GC) remain to be clarified...

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Cited Boster Product(s): RIPA Lysis Buffer (AR0105)

MicroRNA-122 negatively associates with peroxiredoxin-II expression in human gefitinib-resistant lung cancer stem cells

Authors: Chandimali, N., Huynh, D.L., Zhang, J.J., Lee, J.C., Yu, D.Y...
Journal: Cancer Gene Therapy

Previously, we demonstrated that Prx II is important for survival of the gefitinib-resistant A549 (A549/GR) cell line, an NSCLC cell line derived by repeated exposure to gefitinib. Therefore, in this study, we used A549/GR cells to investigate...

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Cited Boster Product(s): Anti-PROM1 Antibody (PA2049)

Mechanical stress protects against osteoarthritis via regulation of the AMPK/NF‐κB signaling pathway

Authors: Yang, Y., Wang, Y., Kong, Y., Zhang, X., Zhang, H., Gang, Y...
Journal: Journal of Cellular Physiology

Mechanical stress plays a key role in regulating cartilage degradation in osteoarthritis (OA). The aim of this study was to evaluate the effects and mechanisms of mechanical stress on articular cartilage. A total of 80 male Sprague‐Dawley...

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Cited Boster Product(s): Cytoplasmic & Nuclear Protein Extraction Kit (AR0106)

IL-2Rα up-regulation is mediated by latent membrane protein 1 and promotes lymphomagenesis and chemotherapy resistance in natural killer/T-cell lymphoma

Authors: Wang, L., Bi, X.W., Zhu, Y.J., He, Y.Z., Lai, Q.Y., Xia, Z.J...
Journal: Cancer Communications

Background: Natural killer/T-cell lymphoma (NKTCL) is a highly aggressive non-Hodgkin lymphoma often resistant to chemotherapy. Serum level of soluble IL-2 receptor α (IL-2Rα) is elevated in NKTCL patients and correlates...

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Cited Boster Product(s): Goat Anti-Rabbit IgG (H+L) Secondary Antibody, HRP Conjugate (BA1054)