Research Spotlight - May 2021

This month, we share some of the latest research studies that explore the underlying mechanisms in disease progressions investigated by scientists whom Boster has served.

Our May edition of Research Spotlight includes a mix of topics about myopia, breast cancer, DNA damage, and inflammatory response progressions. Find out more about the essential roles of several compounds and novel treatments in modulating the responses of signalling pathways.

Scroll down to learn more about these new scientific discoveries.

Aberrant TGF-β1 Signaling Activation by MAF Underlies Pathological Lens Growth in High Myopia

Authors: Zhu, X., Du, Y., Li, D., Xu, J., Wu, Q., He, W., Zhang, K., Zhu, J…
Journal: Nature Communications

High myopia is a leading cause of blindness worldwide. Myopia progression may lead to pathological changes of lens and affect the outcome of lens surgery, but the underlying mechanism remains unclear. Here, we find an increased lens size in highly myopic eyes associated with up-regulation of β/γ-crystallin expressions. Similar findings are replicated in two independent...

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Cited Boster Product(s): Human TGF Beta 1 ELISA Kit PicoKine™ (EK0513)

Cu-Induced Spermatogenesis Disease is Related to Oxidative stress-Mediated Germ Cell Apoptosis and DNA Damage

Authors: Guo, H., Ouyang, Y., Wang, J., Cui, H., Deng, H., Zhong, X., Jian, Z…
Journal: Journal of Hazardous Materials

Copper is considered as an indispensable trace element for living organisms. However, over-exposure to Cu can lead to adverse health effects on human. In this study, CuSO4 decreased sperm concentration and motility, increased sperm malformation rate. Concurrently, testicular damage including testicular histopathological aberrations...

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Cited Boster Product(s): Goat Anti-Mouse IgG (H+L) Secondary Antibody, Biotin Conjugated (BA1001)

Light-Induced Dynamic RGD Pattern for Sequential Modulation of Macrophage Phenotypes

Authors: Luo, Y., Zheng, X., Yuan, P., Ye, X., Ma, L.
Journal: Bioactive Materials

Due to the critical roles of macrophage in immune response and tissue repair, harnessing macrophage phenotypes dynamically to match the tissue healing process on demand attracted many attentions. Although there have developed many advanced platforms with dynamic features for cell manipulation, few studies have designed a dynamic...

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Cited Boster Product(s): Mouse TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine™ (EK0527); Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine™ (EK0394); Mouse IL-10/Interleukin-10 ELISA Kit PicoKine™ (EK0417); Mouse TGF Beta 1 ELISA Kit PicoKine™ (EK0515)

VRK2 is Involved in the Innate Antiviral Response by Promoting Mitostress-Induced mtDNA Release

Authors: He, W.R., Cao, L.B., Yang, Y.L., Hua, D., Hu, M.M., Shu, H.B.
Journal: Cellular & Molecular Immunology

Mitochondrial stress (mitostress) triggered by viral infection or mitochondrial dysfunction causes the release of mitochondrial DNA (mtDNA) into the cytosol and activates the cGAS-mediated innate immune response. The regulation of mtDNA release upon mitostress remains uncharacterized. Here, we identified mitochondria-associated...

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Cited Boster Product(s): Mouse CXCL10/IP-10 ELISA Kit PicoKine™ (EK0736)

LncRNA SNHG6 Promotes G1/S-Phase Transition in Hepatocellular Carcinoma by Impairing miR-204-5p-Mediated Inhibition of E2F1

Authors: Chen, K., Hou, Y., Liao, R., Li, Y., Yang, H., Gong, J.
Journal: Oncogene

Emerging evidence suggests that long noncoding RNAs (lncRNAs) function as competitive endogenous RNA (ceRNA) targeting proteins and genes; however, the role of lncRNAs in hepatocellular carcinoma (HCC) is not well understood. We investigated the mechanism by which lncRNA SNHG6 promotes the development of HCC. RT-qPCR revealed...

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Cited Boster Product(s): RIPA Lysis Buffer (AR0105-100)

Exposure to Constant Light Impairs Cognition with FTO Inhibition and m6A-Dependent TrκB Repression in Mouse Hippocampus

Authors: Yang, Y., Feng, Y., Hu, Y., Liu, J., Shi, H., Zhao, R.
Journal: Environmental Pollution

N6-methyladenosine (m6A) mRNA methylation plays a role in various brain functions. Exposure to chronic constant light (CCL) has been reported to impair cognition, yet whether the underlying mechanism involves m6A remains unknown. In this study, mice exposed to CCL for 3 weeks show impaired cognitive behavior, which was associated...

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Cited Boster Product(s): HRP Conjugated Goat Anti-Mouse IgG SABC Kit (SA1021); HRP Conjugated Goat Anti-Rabbit IgG SABC Kit (SA1022)

Increased Telomerase Activity in Major Depressive Disorder with Melancholic Features: Possible Role of Pro-Inflammatory Cytokines and the Brain-Derived Neurotrophic Factor

Authors: Çavuşoğlu, P.B., İscan, E., Güneş, A., Atabey, N., Alkın, T.
Journal: Brain, Behavior, & Immunity - Health

The biological mechanisms responsible for depression symptoms are not yet understood. For this reason, it is important to reveal the etiopathogenetic mechanisms in this disease. This study aims to compare the levels of pro-inflammatory cytokines, Brain-Derived Neurotrophic Factor (BDNF), and telomerase activity in patients with major...

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Cited Boster Product(s): Human IL-6/Interleukin-6 ELISA Kit PicoKine™ (EK0410); Human IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine™ (EK0392); Human TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine™ (EK0525)

Dichlorvos Poisoning Caused Chicken Cerebrum Tissue Damage and Related Apoptosis-Related Gene Changes

Authors: Gu, Y., Li, G., Huang, C., Liu, P., Hu, G., Wu, C., Xu, Z., Guo, X., Li, P.
Journal: Science of The Total Environment

Dichlorvos (DDVP) is an organophosphorus compound with insecticidal effects. Organophosphorus pesticides can easily enter humans or animals through various channels, causing cerebrum nerve cell damage. The purpose of this research was to investigate whether acute dichlorvos poisoning can cause cerebrum neurotoxic injury and change...

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Cited Boster Product(s): 4% Paraformaldehyde (PFA) Solution In PBS (AR1068)

MCPIP1-Mediated NFIC Alternative Splicing Inhibits Proliferation of Triple-Negative Breast Cancer via Cyclin D1-Rb-E2F1 Axis

Authors: Chen, F., Wang, Q., Yu, X., Yang, N., Wang, Y., Zeng, Y., Zheng, Z...
Journal: Cell Death & Disease

Triple-negative breast cancer (TNBC) is the most aggressive subtype with the worst prognosis and the highest metastatic and recurrence potential, which represents 15–20% of all breast cancers in Chinese females, and the 5-year overall survival rate is about 80% in Chinese women. Recently, emerging evidence suggested that aberrant...

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Cited Boster Product(s): Goat Anti-Rabbit IgG (H+L) Secondary Antibody, Cy3 Conjugated (BA1032)

Beta-Guanidinopropionic Acid has Age-Specific Effects on Markers of Health and Function in Mice

Authors: Dorigatti, J.D., Thyne, K.M., Ginsburg, B.C., Salmon, A.B.
Journal: GeroScience

AMP-activated protein kinase (AMPK) is a central regulator of both lifespan and health across multiple model organisms. β-Guanidinopropionic acid (GPA) is an endogenous AMPK activator previously shown to improve metabolic function in young and obese mice. In this study, we tested whether age of administration significantly affects...

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Cited Boster Product(s): Mouse LBP ELISA Kit PicoKine™ (EK1274)