Research Spotlight - March 2021

In our March edition of Research Spotlight, we present 10 latest research papers from scientists whom Boster has served.

Scientists explore the roles of various pathways associated with tumor development, and how they may emerge as new therapeutic targets for tumor metastasis. Several research studies also reveal the active role of gut microbiota in immunity and disease progressions as well as the effect of several compounds on the functionality and ecology of gut microbiome.

Take a look below to learn more about these new research findings.

Fecal Microbiota Transplantation in HIV: A Pilot Placebo-Controlled Study

Authors: Serrano-Villar, S., Talavera-Rodríguez, A., Gosalbes, M.J., Madrid, N...
Journal: Nature Communications

Changes in the microbiota have been linked to persistent inflammation during treated HIV infection. In this pilot double-blind study, we study 30 HIV-infected subjects on antiretroviral therapy (ART) with a CD4/CD8 ratio less than 1 randomized to either weekly fecal microbiota capsules or placebo for 8 weeks. Stool donors were rationally...

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Cited Boster Product(s): Human LBP ELISA Kit PicoKine™ (EK1271); Human FABP2/I-FABP ELISA Kit PicoKine™ (EK1410)

DDR2 Upregulation Confers Ferroptosis Susceptibility of Recurrent Breast Tumors Through the Hippo Pathway

Authors: Lin, C.C., Yang, W.H., Lin, Y.T., Tang, X., Chen, P.H., Ding, C.K.C...
Journal: Oncogene

Recurrent breast cancer presents significant challenges with aggressive phenotypes and treatment resistance. Therefore, novel therapeutics are urgently needed. Here, we report that murine recurrent breast tumor cells, when compared with primary tumor cells, are highly sensitive to ferroptosis. Discoidin Domain Receptor Tyrosine...

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Cited Boster Product(s): Anti-DDR2 Antibody (PA1879)

Development of a Novel RNAi Therapy: Engineered miR-31 Exosomes Promoted the Healing of Diabetic Wounds

Authors: Huang, J., Yu, M., Yin, W., Liang, B., Li, A., Li, J., Li, X., Zhao, S...
Journal: Bioactive Materials

Rationale: Chronic wounds associated with diabetes exact a heavy burden on individuals and society and do not have a specific treatment. Exosome therapy is an extension of stem cell therapy, and RNA interference (RNAi)-based therapy is a type of advanced precision therapy. Based on the discovery of chronic wound-related genes in...

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Cited Boster Product(s): BCIP/ NBT Chromogenic Substrate Kit (AR1023)

ILT4 Inhibition Prevents TAM- and Dysfunctional T Cell-mediated Immunosuppression and Enhances the Efficacy of Anti-PD-L1 Therapy in NSCLC with EGFR Activation

Authors: Chen, X., Gao, A., Zhang, F., Yang, Z., Wang, S., Fang, Y., Li, J...
Journal: Theranostics

Rationale: Immune checkpoint inhibitors (ICIs) against the PD-1/PD-L1 pathway showed limited success in non-small cell lung cancer (NSCLC) patients, especially in those with activating epidermal growth factor receptor (EGFR) mutations. Elucidation of the mechanisms underlying EGFR-mediated tumor immune escape and the development of...

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Cited Boster Product(s): Human MCP-1 / CCL2 ELISA Kit PicoKine™ (EK0441); Human Rantes ELISA Kit PicoKine™ (EK0494)

Maintaining Manganese in Tumor to Activate cGAS-STING Pathway Evokes a Robust Abscopal Anti-tumor Effect

Authors: Wang, C., Sun, Z., Zhao, C., Zhang, Z., Wang, H., Liu, Y., Guo, Y...
Journal: Journal of Controlled Release

Radiotherapy (RT)-induced DNA damage leaked into cytosol can elicit host antitumor immune response. However, such response rate is unpromising due to limited cyclic GMP-AMP synthase (cGAS) recognition of cytosolic DNA, which could be digested inherently by host DNases. Here we show that synchronizing Mn2+ delivery with accumulated...

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Cited Boster Product(s): Broad Spectrum Protease Inhibitor Cocktail (EDTA Free) (100x) (AR1182-1); Broad Spectrum Phosphatase Inhibitor Cocktail (AR1183)

Value Added Immunoregulatory Polysaccharides of Hericium erinaceus and Their Effect on the Gut Microbiota

Authors: Yang, Y., Ye, H., Zhao, C., Ren, L., Wang, C., Georgiev, M.I., Xiao, J...
Journal: Carbohydrate Polymers

Hericium erinaceus polysaccharides (HEPs) were isolated from the fruiting bodies of H. erinaceus with 53.36 % total carbohydrates and 32.56 % uronic acid. To examine whether HEPs can alter the diversity and the abundance of gut microbiota, juvenile and adult mice were fed with HEPs for 28 days. Based on the result of 16S sequencing...

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Cited Boster Product(s): SDS-PAGE Gel Preparation Kit (AR0138); Mouse TNF Alpha ELISA Kit PicoKine™ (EK0527); Mouse IL-6 ELISA Kit PicoKine™ (EK0411); Mouse IL-10 ELISA Kit PicoKine™ (EK0417); Mouse IFN Gamma / IFNG / Interferon Gamma ELISA Kit PicoKine™ (EK0375)

microRNA-199a-5p Accelerates Nucleus Pulposus Cell Apoptosis and Intervertebral Disc Degeneration by Inhibiting SIRT1-mediated Deacetylation of p21

Authors: Sun, Y., Wang, X., Fu, G., Geng, X.
Journal: Molecular Therapy: Nucleic Acids

Intervertebral disc degeneration (IVDD) is a multifactorial pathological process associated with low back pain in which nucleus pulposus cell senesce is disrupted. Increasing evidence reveals that IVDD can be modulated by microRNAs (miRNAs or miRs). In the current study, we set out to elucidate the role of miR-199a-5p in nucleus...

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Cited Boster Product(s): RIPA Lysis Buffer (AR0105-100); BCA Protein Assay Kit (AR0146)

Low-frequency Electromagnetic Fields Combined with Tissue Engineering Techniques Accelerate Intervertebral Fusion

Authors: Li, W., Huang, C., Ma, T., Wang, J., Liu, W., Yan, J., Sheng, G...
Journal: Stem Cell Research & Therapy

Background: Intervertebral fusion is the most common surgery to treat lumbar degenerative disease (LDD). And the graft material used in the operation is derived from the iliac crest to promote fusion. However, autografts possess the fatal disadvantage of lack of source. Therefore, economical and practical bone substitutes are urgently...

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Cited Boster Product(s): Phosphate Buffered Saline (PBS) Powder (AR0030); BCA Protein Assay Kit (AR0146); Goat Anti-Rabbit IgG (H+L) Secondary Antibody, Cy3 Conjugated (BA1032); Goat Anti-Mouse IgG (H+L) Secondary Antibody, FITC Conjugated (BA1101)

Berberine Promotes Induction of Immunological Tolerance to an Allograft via Downregulating Memory CD8+ T-Cells Through Altering the Gut Microbiota

Authors: Qiu, F., Lu, W., Ye, S., Liu, H., Zeng, Q., Huang, H., Liang, C.L...
Journal: Frontiers in Immunology

Emerging evidence has linked the gut microbiota dysbiosis to transplant rejection while memory T-cells pose a threat to long-term transplant survival. However, it's unclear if the gut microbiome alters the formation and function of alloreactive memory T-cells. Here we studied the effects of berberine, a narrow-spectrum antibiotic...

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Cited Boster Product(s): Mouse IFN Gamma / IFNG / Interferon Gamma ELISA Kit PicoKine™ (EK0375); Mouse IL-17/IL-17A ELISA Kit PicoKine™ (EK0431)

Mechanism Behind the Neuronal Ephaptic Coupling During Synchronizing by Specific Brain-triggered Wave as Neuronal Motor Toolkit

Authors: Karami, S., Doroodmand, M.M., Taherianfar, M., Mutabi-Alavi, A...
Journal: Scientific Reports

Probable mechanism behind the neuronal ephaptic coupling is investigated based on the introduction of “Brain”-triggered potential excitation signal smartly with a specific very low frequency (VLF) waves as a neuronal motor toolkit. Detection of this electric motor toolkit is attributed to in-vitro precise analyses of a neural network...

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Cited Boster Product(s): Anti-Beta III Tubulin TUBB3 Rabbit Monoclonal Antibody (M01857-1)