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Research Spotlight – March 2020
In our March edition of Research Spotlight, we feature 10 recently published research papers from scientists whom Boster has served.
Scroll down to learn more about these new scientific discoveries.
Berberine prevents primary peritoneal adhesion and adhesion reformation by directly inhibiting TIMP-1
Authors: Liu, X., Wei, Y., Bai, X., Li, M., Li, H., Wang, L., Zhang, S., Li, X., Zhao, T...
Journal: Acta Pharmaceutica Sinica B
Peritoneal adhesions are fibrous tissues that tether organs to one another or to the peritoneal wall and represent the major cause of postsurgical morbidity. Enterolysis at repeat surgeries induces adhesion reformation that is more difficult to prevent than primary adhesion. Here we studied the preventive effects of different approaches of berberine...
Cited Boster Product(s): Human TIMP-1 ELISA Kit PicoKine™ (EK0520); Human MMP-3 ELISA Kit PicoKine™ (EK0461); Human MMP-8 ELISA Kit PicoKine™ (EK0464)
Tracing tumorigenesis in a solid tumor model at single-cell resolution
Authors: Praktiknjo, S.D., Obermayer, B., Zhu, Q., Fang, L., Liu, H., Quinn, H...
Journal: Nature Communications
Characterizing the complex composition of solid tumors is fundamental for understanding tumor initiation, progression and metastasis. While patient-derived samples provide valuable insight, they are heterogeneous on multiple molecular levels, and often originate from advanced tumor stages. Here, we use single-cell transcriptome...
Cited Boster Product(s): Anti-Kallikrein 1/KLK1 Antibody (PA1709)
CCL3/CCR1 mediates CD14+CD16− circulating monocyte recruitment in knee osteoarthritis progression
Authors: Zhao, X., Gu, M., Xu, X., Wen, X., Yang, G., Li, L., Sheng, P., & Meng, F.
Journal: Osteoarthritis and Cartilage
Objectives: Monocyte-derived macrophages, as the predominant immune cell type that is increased in inflamed synovium, play a vital role during knee osteoarthritis (KOA) progression. However, the mechanisms underlying the recruitment of circulating monocytes to osteoarthritic knees remain uncertain. Based on previous data obtained from plasma...
Cited Boster Product(s): Human MCP-1 / CCL2 ELISA Kit PicoKine™ (EK0441); Human MIP-1Alpha/CCL3 ELISA Kit PicoKine™ (EK0448); Human CCL4/MIP-1 Beta ELISA Kit PicoKine™ (EK0450)
Farrerol Directly Targets GSK-3β to Activate Nrf2-ARE Pathway and Protect EA.hy926 Cells against Oxidative Stress-Induced Injuries
Authors: Yan, C., Zhang, X., Miao, J., Yuan, H., Liu, E., Liang, T., & Li , Q.
Journal: Oxidative Medicine and Cellular Longevity
Oxidative stress-mediated endothelial injury is considered to be involved in the pathogenesis of various cardiovascular diseases. Farrerol, a typical natural flavanone from the medicinal plant Rhododendron dauricum L., has been reported to show protective effects against oxidative stress-induced endothelial injuries in our previous...
Cited Boster Product(s): DAPI for nucleic acid staining (AR1176); RIPA Lysis Buffer (AR0105); SDS-PAGE Protein Loading Buffer 5X (Reducing) (AR1112); BCA Protein Assay Kit (AR0146)
Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities
Authors: Ikezu, S., Yeh, H., Delpech, J.C., Woodbury, M.E., Van Enoo, A.A., Ruan, Z...
Journal: Molecular Psychiatry
Maternal immune activation (MIA) disrupts the central innate immune system during a critical neurodevelopmental period. Microglia are primary innate immune cells in the brain although their direct influence on the MIA phenotype is largely unknown. Here we show that MIA alters microglial gene expression with upregulation of cellular...
Cited Boster Product(s): Mouse TrkB ELISA Kit PicoKine™ (EK0849)
Programmable prodrug micelle with size-shrinkage and charge-reversal for chemotherapy-improved IDO immunotherapy
Authors: Dai, L., Li, X., Yao, M., Niu, P., Yuan, X., Li, K., Chen, M., Fu, Z., Duan, X...
Journal: Biomaterials
IDO blockade-based immunotherapy has been impeded by the activation of antitumor immune response and low delivery efficiency of immunotherapeutic, resulting from natural biological barriers and immune resistance. Herein, a programmable drug delivery nanosystem with enhanced tumor penetration and endocytosis is...
Cited Boster Product(s): Goat Anti-Mouse IgG (H+L) Secondary Antibody, HRP Conjugate (BA1050); Goat Anti-Rabbit IgG (H+L) Secondary Antibody, HRP Conjugate (BA1054)
Cell immaturity and white/beige adipocyte potential of primary human adipose‐derived stromal cells are restrained by culture‐medium TGFβ1
Authors: Leménager, H., Fiévet, L.M.A., Guilloton, F., Naji, A., Descamps, J.G...
Journal: Stem Cells
Human adipose‐derived stem/stromal cells (hASCs) can differentiate into specialized cell types and thereby contribute to tissue regeneration. As such, hASCs have drawn increasing attention in cell therapy and regenerative medicine, not to mention the ease to isolate them from donors. Culture conditions are critical for expanding hASCs while maintaining...
Cited Boster Product(s): Human TGF Beta 1 ELISA Kit PicoKine™ (EK0513); Bovine TGF Beta 1 ELISA Kit PicoKine™ (EK0513-BV)
Cadmium ingestion exacerbates Salmonella infection, with a loss of goblet cells through activation of Notch signaling pathways by ROS in the intestine
Authors: Xie, S., Jiang, L., Wang, M., Sun, W., Yu, S., Turner, J.R., & Yu, Q.
Journal: Journal of Hazardous Materials
Whether cadmium ingestion affects the susceptibility to infection and the detailed mechanism have not been investigated. We aimed to evaluate the effects of cadmium on the intestinal mucosal barrier and Salmonella infection. We found that oral administration of cadmium caused damage to the intestinal mucosal barrier, with body weight loss, an...
Cited Boster Product(s): Mouse TNF Alpha ELISA Kit PicoKine™ (EK0527)
Zerumbone ameliorates behavioral impairments and neuropathology in transgenic APP/PS1 mice by suppressing MAPK signaling
Authors: Li, L., Wu, X.H., Zhao, X.J., Xu, L., Pan, C.L., & Zhang, Z.Y.
Journal: Journal of Neuroinflammation
Background: Alzheimer’s disease (AD) is a major clinical problem, but there is a distinct lack of effective therapeutic drugs for this disease. We investigated the potential therapeutic effects of zerumbone, a subtropical ginger sesquiterpene, in transgenic APP/PS1 mice, rodent models of AD which exhibit cerebral amyloidosis and...
Cited Boster Product(s): Phosphate Buffered Saline (PBS) Powder (AR0030)
Relationship of Microbial Profile With Airway Immune Response in Eosinophilic or Neutrophilic Inflammation of Asthmatics
Authors: Son, J.H., Kim, J.H., Chang, H.S., Park, J.S., & Park, C.S.
Journal: Allergy, Asthma & Immunology Research
Purpose: Different characteristics of airway microbiome in asthmatics may lead to differential immune responses, which in turn cause eosinophilic or neutrophilic airway inflammation. However, the relationships among these factors have yet to be fully elucidated. Methods: Microbes in induced sputum samples were subjected to sequence...
Cited Boster Product(s): Human IL-17E/IL-25 ELISA Kit PicoKine™ (EK0793)
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