Research Spotlight - June 2022

The June issue of Research Spotlight highlights research advancements from scientists whom we have served.

Read about new studies outlining potential treatments to promote tissue repair and regeneration. For example, one study demonstrated the significance of EE for cardiac repair.

Scientists also investigated the promising roles of ROS-scavenging hydrogel, responsive Mn3O4 nanoplatform, and a novel 3D-printed porous bioactive ceramic scaffold for spinal cord injury, gastric cancer, and bone injury, respectively.

Other papers uncovered the molecular mechanisms of SIRT1, Neat1, cathepsin B/NLRP3, and FASN in different diseases and cancer.

Scroll down to learn more about these 10 research discoveries.

Environmental Eustress Improves Postinfarction Cardiac Repair via Enhancing Cardiac Macrophage Survival

Authors: Bai, P.Y., Chen, S.Q., Jia, D.L., Pan, L.H., Liu, C.B., Luo, J.L., Yang, Y…
Journal: Science Advances

Macrophages play a vital role in cardiac repair following myocardial infarction (MI). An enriched environment (EE) is involved in the regulation of macrophage-related activities and disease progression; however, whether EE affects the phenotype and function of macrophages to improve postinfarction cardiac repair remains unknown...

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Cited Boster Product(s): Mouse BDNF ELISA Kit PicoKine® (EK0309)

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Catalpol Enhances Random-Pattern Skin Flap Survival by Activating SIRT1-Mediated Enhancement of Autophagy

Authors: Jiang, R.H., Dong, C.J., Chen, Z.L., Cheng, S., Yang, J.X., Gao, W.Y.
Journal: Oxidative Medicine and Cellular Longevity

Random-pattern skin flap necrosis limits its application in the clinic. It is still a challenge for plastic surgeons. Catalpol is an effective ingredient extracted from Rehmannia glutinosa, which is reported to promote angiogenesis and protect against ischemic cerebral disease. The aim of our experiment is to assess whether catalpol...

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Cited Boster Product(s): Anti-VE-Cadherin-5 Cdh5-Antibody Picoband™ (A02632-2)

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Mitochondria Supply Sub-Lethal Signals for Cytokine Secretion and DNA-Damage in H. pylori Infection

Authors: Dörflinger, B., Badr, M.T., Haimovici, A., Fischer, L., Vier, J., Metz, A…
Journal: Cell Death & Differentiation

The bacterium Helicobacter pylori induces gastric inflammation and predisposes to cancer. H. pylori-infected epithelial cells secrete cytokines and chemokines and undergo DNA-damage. We show that the host cell’s mitochondrial apoptosis system contributes to cytokine secretion and DNA-damage in the absence of cell death. H. pylori...

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Cited Boster Product(s): Human VEGF ELISA Kit PicoKine® (EK0539)

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A Reactive Oxygen Species-Responsive Hydrogel Encapsulated with Bone Marrow Derived Stem Cells Promotes Repair and Regeneration of Spinal Cord Injury

Authors: Li, Z., Zhao, T., Ding, J., Gu, H., Wang, Q., Wang, Y., Zhang, D...
Journal: Bioactive Materials

Spinal cord injury (SCI) is an overwhelming and incurable disabling event accompanied by complicated inflammation-related pathological processes, such as excessive reactive oxygen species (ROS) produced by the infiltrated inflammatory immune cells and released to the extracellular microenvironment, leading to the widespread apoptosis...

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Cited Boster Product(s): Rat TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine® (EK0526); Rat IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine® (EK0393); Rat IL-6/Interleukin-6 ELISA Kit PicoKine® (EK0412)

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Neat1 Promotes Acute Kidney Injury to Chronic Kidney Disease by Facilitating Tubular Epithelial Cells Apoptosis via Sequestering miR-129-5p

Authors: Ma, T., Li, H., Liu, H., Peng, Y., Lin, T., Deng, Z., Jia, N., Chen, Z...
Journal: Molecular Therapy

Acute kidney injury (AKI) is increasingly identified as a crucial risk factor for progression to CKD. However, the factors governing AKI to CKD progression remain largely unknown. By high-throughput RNA sequencing, we found that Neat1_2, a transcript variant of Neat1, was upregulated in 40-min ischemia/reperfusion injury (IRI), which...

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Cited Boster Product(s): HRP Conjugated AffiniPure Goat Anti-Mouse IgG (H+L) (BA1050); HRP Conjugated AffiniPure Goat Anti-Rabbit IgG (H+L) (BA1054)

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Co-Exposure of Chronic Stress and Alumina Nanoparticles Aggravates Hippocampal Microglia Pyroptosis by Activating Cathepsin B/NLRP3 Signaling Pathway

Authors: Zhang, H., Wang, J., Ruan, C., Gao, Z., Zhu, Q., Li, S.
Journal: Journal of Hazardous Materials

Combined exposure of chronic stress and alumina nanoparticles (AlNPs) aggravates hippocampal injury, but the pathogenesis is unevaluated. This study aimed to investigate the effect and mechanism of co-exposure to chronic stress and AlNPs on hippocampal microglia pyroptosis. In this study, chronic restraint stress (CRS) alone caused...

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Cited Boster Product(s): Rat IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine® (EK0393); Rat IL-18/IL-1F4/Interleukin-18 ELISA Kit PicoKine® (EK0592)

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Tumor Microenvironment Responsive Mn3O4 Nanoplatform for in vivo Real-Time Monitoring of Drug Resistance and Photothermal/Chemodynamic Synergistic Therapy of Gastric Cancer

Authors: Li, H., Cai, X., Yi, T., Zeng, Y., Ma, J., Li, L., Pang, L., Li, N., Hu, H…
Journal: Journal of Nanobiotechnology

Background: Postoperative chemotherapy for gastric cancer often causes multidrug resistance (MDR), which has serious consequences for therapeutic effects. Individualized treatment based on accurate monitoring of MDR will greatly improve patient survival. Results: In this article, a self-enhanced Mn3O4 nanoplatform (MPG NPs) was...

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Cited Boster Product(s): DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) For Nucleic Acid Staining (AR1176)

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Pore Size of 3D-Printed Polycaprolactone/Polyethylene Glycol/Hydroxyapatite Scaffolds Affects Bone Regeneration by Modulating Macrophage Polarization and the Foreign Body Response

Authors: Li, W., Dai, F., Zhang, S., Xu, F., Xu, Z., Liao, S., Zeng, L., Song, L...
Journal: ACS Applied Materials & Interfaces

3D-printed porous bioactive ceramic scaffolds have been widely used in bone defect repair. However, material implantation is often accompanied by a foreign body response (FBR), which may affect host tissue regeneration. The physical properties of biomaterials, including shape, pore size, and porosity, control the relevant immune...

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Cited Boster Product(s): Anti-Mannose Receptor/MRC1 Picoband™ Antibody (A02285-2); Goat Anti-Rabbit IgG (H+L) Secondary Antibody, FITC Conjugated (BA1105); Goat Anti-Rabbit IgG (H+L) Secondary Antibody, Cy3 Conjugated (BA1032)

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FASN Promotes Lymph Node Metastasis in Cervical Cancer via Cholesterol Reprogramming and Lymphangiogenesis

Authors: Du, Q., Liu, P., Zhang, C., Liu, T., Wang, W., Shang, C., Wu, J…
Journal: Cell Death & Disease

Cervical cancer (CC) patients with lymph node metastasis (LNM) have a poor prognosis. Clarification of the detailed mechanisms underlying LNM may provide potential clinical therapeutic targets for CC patients with LNM. However, the molecular mechanism of LNM in CC is unclear. In the present study, we demonstrated that fatty acid...

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Cited Boster Product(s): Human MMP-9 ELISA Kit PicoKine® (EK0465); Human EG-VEGF/PK1/PROK1 ELISA Kit PicoKine® (EK0575); Human Angiogenin/ANG ELISA Kit PicoKine® (EK0305)

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Norepinephrine Activates β1-Adrenergic Receptors at the Inner Nuclear Membrane in Astrocytes

Authors: Benton, K.C., Wheeler, D.S., Kurtoglu, B., Ansari, M.B.Z…
Journal: GLIA

Norepinephrine exerts powerful influences on the metabolic, neuroprotective and immunoregulatory functions of astrocytes. Until recently, all effects of norepinephrine were believed to be mediated by receptors localized exclusively to the plasma membrane. However, recent studies in cardiomyocytes have identified adrenergic receptors...

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Cited Boster Product(s): Anti-Lamin A/C LMNA Antibody (M00438-2)

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