Research Spotlight - June 2021

Our June edition of Research Spotlight presents 10 recent research papers from scientists whom Boster has served.

In the selected studies, you will learn how the research community is developing more efficient ways for drug delivery, utilizing biomaterials in therapeutic treatments, exploring various pathological reactions, and many more.

Among the papers, scientists investigate how the apoptotic process can be used to load drugs for brain-targeted delivery with much higher efficiency than other extracellular vesicles. The role and antioxidant effects of spinach methanolic extract in the prevention of retinal degeneration is also demonstrated.

Scroll down to discover more about each new research publication.

Delivering Antisense Oligonucleotides across the Blood-Brain Barrier by Tumor Cell-Derived Small Apoptotic Bodies

Authors: Wang, Y., Pang, J., Wang, Q., Yan, L., Wang, L., Xing, Z, Wang, C…
Journal: Advanced Science

The blood-brain barrier (BBB) is the most restrictive and complicated barrier that keeps most biomolecules and drugs from the brain. An efficient brain delivery strategy is urgently needed for the treatment of brain diseases. Based on the studies of brain-targeting extracellular vesicles (EVs), the potential of using small apoptotic...

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Cited Boster Product(s): Anti-ZO1 Tight Junction Protein/TJP1 Antibody Picoband™ (PB9234); Anti-RAB11B Antibody Picoband™ (A04526-1)

Calcium Phosphate-Based Materials Regulate Osteoclast-Mediated Osseointegration

Authors: Wang, X., Yu, Y., Ji, L., Geng, Z., Wang, J., Liu, C.
Journal: Bioactive Materials

Calcium phosphate-based materials (CaP) have been widely used as bone graft substitutes with a decent osseointegration. However, the mechanism whereby cells function and repair the bone defect in CaP micro-environment is still elusive. The aim of this study is to find the mechanism how osteoclast behaviors mediate bone healing with...

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Cited Boster Product(s): Mouse RANK / CD265 ELISA Kit PicoKine™ (EK0830)

Calcium Silicate-Human Serum Albumin Composite Hydrogel Decreases Random Pattern Skin Flap Necrosis by Attenuating Vascular Endothelial Cell Apoptosis and Inflammation

Authors: Xu, P., Xing, M., Huang, H., Xue, K., Chang, J., Liu, K.
Journal: Chemical Engineering Journal

Random pattern skin flaps are commonly used in plastic surgery to repair skin defects. However, as flap survival mainly relies on blood supply from the distal pedicle and the wound bed, the distal part of the flap is prone to necrosis. Subsequent pathological reactions, including inflammatory reactions, cell apoptosis, and oxidative...

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Cited Boster Product(s): DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) For Nucleic Acid Staining (AR1176)

Development of Novel Nanofibers Targeted to Smoke-Injured Lungs

Authors: Mercel, A.I., Marulanda, K., Gillis, D.C., Sun, K., Clemons, T.D…
Journal: Biomaterials

Smoke inhalation injury is associated with significant mortality and current therapies remain supportive. The purpose of our study was to identify proteins upregulated in the lung after smoke inhalation injury and develop peptide amphiphile nanofibers that target these proteins. We hypothesize that nanofibers targeted to angiotensin...

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Cited Boster Product(s): Anti-Angiotensin Converting Enzyme 1/ACE Antibody Picoband™ (PB9124)

TRAIL-Armed ER Nanosomes Induce Drastically Enhanced Apoptosis in Resistant Tumor in Combination with the Antagonist of IAPs (AZD5582)

Authors: Hou, H., Su, K., Huang, C., Yuan, Q., Li, S., Sun, J., Lin, Y, Du, Z...
Journal: Advanced Healthcare Materials

Although mesenchymal stem cells (MSCs) can be engineered to deliver the TNF-related apoptosis-inducing ligand (TRAIL) as an effective anticancer therapy, the clinical application is hampered by the costly manufacturing of therapeutic MSCs. Therefore, it is needed to find an alternative cell-free therapy. In this study, TRAIL-armed...

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Cited Boster Product(s): 5nm Colloidal Gold Labeled Secondary Antibody, Goat Anti-Rabbit IgG (H+L) (GA1013)

Bufalin Targets the SRC-3/MIF Pathway in Chemoresistant Cells to Regulate M2 Macrophage Polarization in Colorectal Cancer

Authors: Chen, J., Wang, H., Jia, L., He, J., Li, Y., Liu, H., Wu, R., Qiu, Y...
Journal: Cancer Letters

>M2-polarized macrophages are one of critical factors in tumour chemoresistance. An increasing number of studies have shown that M2 macrophage polarization can be promoted by chemoresistance. A large number of evidences indicate that Bufalin has significant antitumour effect, previous studies have found that Bufalin can reduce the...

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Cited Boster Product(s): Human IL-10/Interleukin-10 ELISA Kit PicoKine™ (EK0416); Human TGF Beta 1 ELISA Kit PicoKine™ (EK0513); Mouse IL-10/Interleukin-10 ELISA Kit PicoKine™ (EK0417); Mouse TGF Beta 1 ELISA Kit PicoKine™ (EK0515)

Metalloproteinase 1 Downregulation in Neurofibromatosis 1: Therapeutic Potential of Antimalarial Hydroxychloroquine and Chloroquine

Authors: Tsuji, G., Yumine, A.T., Kato, T., Furue, M.
Journal: Cell Death & Disease

Neurofibromatosis type 1 is an autosomal dominant genetic disorder caused by mutation in the neurofibromin 1 (NF1) gene. Its hallmarks are cutaneous findings including neurofibromas, benign peripheral nerve sheath tumors. We analyzed the collagen and matrix metalloproteinase 1 (MMP1) expression in Neurofibromatosis 1 cutaneous...

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Cited Boster Product(s): Human MMP-1 ELISA Kit PicoKine™ (EK0458)

Melatonin Alleviates Contrast-Induced Acute Kidney Injury by Activation of Sirt3

Authors: Zhang, C., Suo, M., Liu, L., Qi, Y., Zhang, C., Xie, L., Zheng, X...
Journal: Oxidative Medicine and Cellular Longevity

Oxidative stress and apoptosis play a vital role in the pathogenesis of contrast-induced acute kidney injury (CI-AKI). The purpose of our study was to investigate the protective effects and mechanisms of melatonin against CI-AKI in a CI-AKI mouse model and NRK-52E cells. We established the CI-AKI model in mice, and the animals were...

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Cited Boster Product(s): Anti-Lipocalin 2/LCN2 Antibody Picoband™ (PB9609)

Spinach Methanolic Extract Attenuates the Retinal Degeneration in Diabetic Rats

Authors: Pérez, R.B., Martinez, A.C., Velázquez, E.G., Rosas, M.M...
Journal: Antioxidants

It has been suggested that spinach methanolic extract (SME) inhibits the formation of advanced glycation end products (AGEs), which are increased during diabetes progression, so it is important to know if SME has beneficial effects in the diabetic retina. In this study, in vitro assays showed that SME inhibits glycation, carbonyl...

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Cited Boster Product(s): Anti-Nitric Oxide Synthase (Inducible) Nos2 Antibody (A00368-1)

Proteomics and Transcriptomics Jointly identify the Key Role of Oxidative Phosphorylation in Fluoride-Induced Myocardial Mitochondrial Dysfunction in Rats

Authors: Xie, J., Zhao, Y., Dong, N., Tian, X., Feng, J., Liu, P., Li, M...
Journal: Ecotoxicology and Environmental Safety

The regulation of mitochondrial function, which is dominated by oxidative phosphorylation (OXPHOs), is important in fluoride induced cardiovascular disease. Based on the previous study of fluoride-induced mitochondrial structure and membrane potential abnormalities, this study integrated ITRAQ protein quantification and RNA-Seq...

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Cited Boster Product(s): HRP Conjugated Goat Anti-Rabbit IgG SABC Kit (SA1022); DAB Chromogenic Substrate Kit (Brown) (AR1022)