Research Spotlight - July 2022

The July edition of Research Spotlight presents 10 recent publications from scientists whom Boster has served.

In this month’s edition, a number of research papers discussed novel approaches for repairing cellular defects upon injury. Zhang et al. explored the regenerative potential of functionalized Schwann-like cells converted from GMSCs for repairing severe PNIs. Other studies highlighted the potential clinical transformation of triboelectric stimulation and DMSO pretreatment to rejuvenate aged BMSCs and preserve male fertility, respectively.

Several research studies also provided insights for a more effective drug delivery system with a high therapeutic targeting effect using natural compounds. Some examples include using Notoginsenoside R1 for the myocardial-targeting drug delivery system, quercetin to prevent Cd toxicity, and the immunomodulatory effects of different fucoidans.

Scroll down to learn more about these research discoveries!

Implantation of a Nerve Protector Embedded With Human GMSC-derived Schwann-Like Cells Accelerates Regeneration of Crush-Injured Rat Sciatic Nerves

Authors: Zhang, Q., Burrell, J.C., Zeng, J., Motiwala, F.I., Shi, S., Cullen, D.K…
Journal: Stem Cell Research & Therapy

Background: Peripheral nerve injuries (PNIs) remain one of the great clinical challenges because of their considerable long-term disability potential. Postnatal neural crest-derived multipotent stem cells, including gingiva-derived mesenchymal stem cells (GMSCs), represent a promising source of seed cells for tissue engineering...

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Cited Boster Product(s): Anti-S100B/S100 Beta Rabbit Monoclonal Antibody (M00979-1)

Bone Repairment via Mechanosensation of Piezo1 Using Wearable Pulsed Triboelectric Nanogenerator

Authors: Wang, B., Li, G., Zhu, Q., Liu, W., Ke, W., Hua, W., Zhou, Y…
Journal: Small

Bone repair in real time is a challenging medical issue for elderly patients; this is mainly because aged bone marrow mesenchymal stem cells (BMSCs) possess limited osteogenesis potential and repair capacity. In this study, triboelectric stimulation technology is used to achieve bone repair via mechanosensation of Piezo1 by fabricating...

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Cited Boster Product(s): Human Endothelin 1/EDN1 ELISA Kit PicoKine® (EK0945)

Ube2c-Inhibition Alleviated Amyloid Pathology and Memory Deficits in APP/PS1 Mice Model of AD

Authors: Li, T., Su, Q., Zhang, Z., Zhang, Y., Yang, M., Wang, Z., Guo, J...
Journal: Progress in Neurobiology

Autophagy is a major intracellular degradation pathway for the clearance of damaged organelles and misfolded peptides. Previous studies have indicated that autophagy is involved in the pathogenesis of neurodegenerative disease including Alzheimer’s disease (AD). Defective autophagy and highly expressed ubiquitin-conjugating enzyme 2...

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Cited Boster Product(s): HRP Conjugated AffiniPure Goat Anti-Rabbit IgG (H+L) (BA1054); HRP Conjugated AffiniPure Goat Anti-Mouse IgG (H+L) (BA1050); Goat Anti-Mouse IgG (H+L) Secondary Antibody, FITC Conjugated (BA1101); Goat Anti-Rabbit IgG (H+L) Secondary Antibody, Cy3 Conjugated (BA1032); Plus RIPA Lysis Buffer (AR0102-100); SDS-PAGE Protein Loading Buffer 2X (Reducing) (AR0131-20)

Notoginsenoside R1-Loaded Mesoporous Silica Nanoparticles Targeting the Site of Injury Through Inflammatory Cells Improves Heart Repair After Myocardial Infarction

Authors: Li, H., Zhu, J., Xu, Y.W., Mou, F.F., Shan, X.L., Wang, Q.L., Liu, B.N…
Journal: Redox Biology

Notoginsenoside R1 (NGR1) is the main monomeric component extracted from the dried roots and rhizomes of Panax notoginseng, and exerts pharmacological action against myocardial infarction (MI). Owing to the differences in compound distribution, absorption, and metabolism in vivo, exploring a more effective drug delivery system...

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Cited Boster Product(s): Cytoplasmic And Nuclear Protein Extraction Kit (AR0106)

Neutrophil Extracellular Traps Mediate m6A Modification and Regulates Sepsis-Associated Acute Lung Injury by Activating Ferroptosis in Alveolar Epithelial Cells

Authors: Zhang, H., Liu, J., Zhou, Y., Qu, M., Wang, Y., Guo, K., Shen, R…
Journal: International Journal of Biological Sciences

Neutrophil extracellular traps (NETs) production is a major strategy employed by polymorphonuclear neutrophils (PMNs) to fight against microbes. NETs have been implicated in the pathogenesis of various lung injuries, although few studies have explored NETs in sepsis-associated acute lung injury (SI-ALI). Here, we demonstrate...

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Cited Boster Product(s): Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine® (EK0394); Mouse TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine® (EK0527); Mouse TGF Beta 1 ELISA Kit PicoKine® (EK0515)

Collagen Scaffold Loaded Allogeneic Neural Stem Cells Promoted Locomotion Recovery of Spinal Cord Injury Mainly Through Secreting Neurotrophic Factors

Authors: Liu, S., Fan, C., Xie, Y., Wang, L., Cui, Y., Wang, B.
Journal: Materials & Design

The combination of biological scaffold and neural stem cells (NSCs) is a promising treatment strategy for spinal cord injury (SCI). But adverse niche at injures spinal cord severe hamper the transplanted NSCs to preferentially differentiate neurons. In this study, we compared the therapeutic outcomes in rat completely transected SCI...

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Cited Boster Product(s): Rat NGF/NGF Beta ELISA Kit PicoKine® (EK0471)

Genome-Wide Association Study for Circulating FGF21 in Patients With Alcohol Use Disorder: Molecular Links Between the SNHG16 Locus and Q5 Catecholamine Metabolism

Authors: Ho, M.F., Zhang, C., Moon, I., Wei, L., Coombes, B., Biernacka, J…
Journal: Molecular Metabolism

Objective: Alcohol consumption can increase circulating levels of fibroblast growth factor 21 (FGF21). The effects of FGF21 in the central nervous system are associated with the regulation of catecholamines, neurotransmitters that play a crucial role in reward pathways. This study aims to identify genetic variants associated with FGF21...

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Cited Boster Product(s): Human FGF21 ELISA Kit PicoKine® (EK0994)

Comparative Study of the Immunomodulatory Effects of Different Fucoidans from Saccharina japonica Mediated by Scavenger Receptors on RAW 264.7 Macrophages

Authors: Cui, M., Li, X., Geng, L., Wu, N., Wang, J., Deng, Z., Li, Z., Zhang, Q.
Journal: International Journal of Biological Macromolecules

Scavenger receptors (SRs) have been shown to participate in regulating the immune response of macrophages, and fucoidan from Fucus vesiculosus has been verified as a ligand of class A SRs (SR-A). However, the roles of SRs in the immunomodulatory activity of fucoidan from Saccharina japonica are not clear. Thus, we performed a comparative...

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Cited Boster Product(s): Mouse IL-6/Interleukin-6 ELISA Kit PicoKine® (EK0411); Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine® (EK0394); Mouse TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine® (EK0527)

Dimethyl Sulfoxide Attenuates Radiation-Induced Testicular Injury through Facilitating DNA Double-Strand Break Repair

Authors: Huang, Z., Peng, R., Yu, H., Chen, Z., Wang, S., Wang, Z., Dong, S…
Journal: Oxidative Medicine and Cellular Longevity

The testis is susceptible to ionizing radiation, and male infertility and sexual dysfunction are prevalent problems after whole-body or local radiation exposure. Currently, there is no approved agent for the prevention or treatment of radiation-induced testicular injury. Herein, we investigated the radioprotective effect of dimethyl...

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Cited Boster Product(s): Anti-Vinculin/VCL Antibody Picoband™ (A01207)

Role of Endoplasmic Reticulum Stress in Cadmium-Induced Hepatocyte Apoptosis and the Protective Effect of Quercetin

Authors: Wang, J., Ding, L., Wang, K., Huang, R., Yu, W., Yan, B., Wang, H…
Journal: Ecotoxicology and Environmental Safety

Cadmium (Cd) is one of the most toxic environmental pollutants. Quercetin (Que) is a kind of natural flavonoid with neuroprotective, antioxidant, and free-radical scavenging pharmacological activities. However, whether Que has the protective effect of on Cd-induced rat hepatocyte injury is unclear. This study aimed to determine...

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Cited Boster Product(s): Anti-GRP78 BiP/HSPA5 Antibody (PA1815)