Research Spotlight – July 2020

In our July edition of Research Spotlight, we feature 10 recently published research papers from scientists whom Boster has served.

This month’s research publications examine different types of cancers, including ovarian cancer, breast cancer, colorectal cancer, etc. Scientists also delve into other research fields, such as intervertebral disc (IVD) degeneration, wound healing, and type 2 diabetes.

Scroll down to learn more about these new scientific discoveries.

Accumulation of advanced glycation end products (AGEs) is associated with the severity of aortic stenosis in patients with concomitant type 2 diabetes

Authors: Kopytek, M., Ząbczyk, M., Mazur, P., Undas, A., & Natorska, J.
Journal: Cardiovascular Diabetology

Accumulation of advanced glycation end products (AGEs) leads to chronic glycation of proteins and tissue damage, particularly in patients with diabetes mellitus (DM). We aimed to evaluate whether increased accumulation of AGEs in patients with aortic stenosis (AS) and concomitant type 2 diabetes (DM) is associated with AS severity...

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Cited Boster Product(s): Human Rage ELISA Kit PicoKine™ (EK0827)

Antitumor effect of a WEE1 inhibitor and potentiation of olaparib sensitivity by DNA damage response modulation in triple-negative breast cancer

Authors: Ha, D.H., Min, A., Kim, S., Jang, H., Kim, S.H., Kim, H.J., Ryu, H.S, Ku, J.L...
Journal: Scientific Reports

Due to its regulation of CDK1/2 phosphorylation, WEE1 plays essentially roles in the regulations of G2/M checkpoint and DNA damage response (DDR). WEE1 inhibition can increase genomic instability by inducing replication stress and G2/M checkpoint inactivation, which result in increased cellular sensitivity to DNA damaging agents...

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Cited Boster Product(s): Anti-Phospho-Cdc2 (Tyr15) CDK1 Antibody (P00209)

Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation

Authors: Zhao, Y., Qiu, C., Wang, W., Peng, J., Cheng, X., Shangguan, Y., Xu, M., Li, J...
Journal: Theranostics

Background: Intervertebral disc (IVD) degeneration is a common degenerative disease that can lead to collapse or herniation of the nucleus pulposus (NP) and result in radiculopathy in patients. Methods: NP tissue and cells were isolated from patients and mice, and the expression profile of cortistatin (CST) was analysed. In addition...

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Cited Boster Product(s): IHC Enzyme Antigen Retrieval Reagent (AR0022)

Bio-multifunctional alginate/chitosan/fucoidan sponges with enhanced angiogenesis and hair follicle regeneration for promoting full-thickness wound healing

Authors: Hao, Y., Zhao, W., Zhang, L., Zeng, X., Sun, Z., Zhang, D., Shen, P., Li, Z...
Journal: Materials & Design

Developing bio-multifunctional wound dressings with excellent hemostasis, antibacterial, anti-inflammatory, enhanced angiogenesis and hair follicle regeneration for promoting full-thickness wound healing is highly valuable in clinical application. Herein, bio-multifunctional composite sponges were prepared by coupling alginate and chitosan with fucoidan...

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Cited Boster Product(s): 4% Paraformaldehyde (PFA) Solution In PBS (AR1068)

TRPV1 Antagonist DWP05195 Induces ER Stress-Dependent Apoptosis through the ROS-p38-CHOP Pathway in Human Ovarian Cancer Cells

Authors: Wang, Y.Y., Lee, K.T., Lim, M.C., & Choi, J.H.
Journal: Cancers

In addition to their analgesic activity, transient receptor potential vanilloid 1 (TRPV1) agonists and antagonists demonstrate profound anti-cancer activities in various human cancers. In the present study, we investigated the anti-cancer activity of a novel TRPV1 antagonist, DWP05195, and evaluated its molecular mechanism in human ovarian cancer cells...

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Cited Boster Product(s): Tris Buffered Saline (TBS) Powder (AR0031)

Low-intensity pulsed ultrasound upregulates osteogenesis under inflammatory conditions in periodontal ligament stem cells through unfolded protein response

Authors: Li, H., Deng, Y., Tan, M., Feng, G., Kuang, Y., Li, J., & Song, J.
Journal: Stem Cell Research & Therapy

In periodontal tissue engineering, periodontal ligament stem cells derived from patients with periodontitis (P-PDLSCs) are among the most promising and accessible stem cells for repairing disrupted alveolar bone and other connective tissues around the teeth. However, the inflammatory environment influences the osteogenic...

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Cited Boster Product(s): Human IL-6 ELISA Kit PicoKine™ (EK0410); Human IL-8 ELISA Kit PicoKine™ (EK0413)

Comparative studies of the expression of creatine kinase isoforms under immune stress in Pelodiscus sinensis

Authors: Li, C., Wang, W., Lee, J., Zeng, L., Yang, Y., Yin, S.J., Park, Y.D, & Qian, G.Y.
Journal: International Journal of Biological Macromolecules

The expression and localization of different isoforms of creatine kinase in Pelodiscus sinensis (PSCK) were studied to reveal the role of PSCK isozymes (PSCK-B, PSCK-M, PSCK-S) under bacterial infection-induced immunologic stress. The computational molecular dynamics simulations predicted that PSCK-S would mostly possess a kinase function in a structural...

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Cited Boster Product(s): HRP Conjugated Goat Anti-Rabbit IgG SABC Kit (SA1022)

MicroRNA-320d regulates tumor growth and invasion by promoting FoxM1 and predicts poor outcome in gastric cardiac adenocarcinoma

Authors: Chen, X., Gao, S., Zhao, Z., Liang, G., Kong, J., & Feng, X.
Journal: Cell & Bioscience

Recent evidences demonstrate that dysregulated expression of microRNA-320d (miR-320d) has been associated with several cancer development and progression. However the effect of miR-320d on gastric cardiac adenocarcinoma (GCA) and the association of miR-320d with its potential gene target FoxM1 remain unclear...

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Cited Boster Product(s): Goat Anti-Rabbit IgG (H+L) Secondary Antibody, Biotin Conjugate (BA1003); HRP Conjugated Streptavidin (BA1088); Goat Anti-Rabbit IgG (H+L) Secondary Antibody, HRP Conjugate (BA1054)

Hypoglycemic mechanism of polysaccharide from Cyclocarya paliurus leaves in type 2 diabetic rats by gut microbiota and host metabolism alteration

Authors: Li, Q., Hu, J., Nie, Q., Chang, X., Fang, Q., Xie, J., Li, H., & Nie, S.
Journal: Science China Life Sciences

Diabetes mellitus is a serious threat to human health. Cyclocarya paliurus (Batal.) Iljinskaja (C.paliurus) is one of the traditional herbal medicine and food in China for treating type 2 diabetes, and the C. paliurus polysaccharides (CP) were found to be one of its major functional constituents. This research aimed at...

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Cited Boster Product(s): Rat IL-1 Beta ELISA Kit PicoKine™ (EK0393); Rat IL-6 ELISA Kit PicoKine™ (EK0412); Rat TNF Alpha ELISA Kit PicoKine™ (EK0526)

Multi-omics analysis to identify driving factors in colorectal cancer

Authors: Xu, X., Gong, C., Wang, Y., Hu, Y., Liu, H., & Fang, Z.
Journal: Epigenomics

Aim: We aim to identify driving genes of colorectal cancer (CRC) through multi-omics analysis. Materials & methods: We downloaded multi-omics data of CRC from The Cancer Genome Atlas dataset. Integrative analysis of single-nucleotide variants, copy number variations, DNA methylation and differentially expressed genes identified candidate...

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Cited Boster Product(s): Cell Counting Kit-8 (CCK-8) (AR1160)